Recombinant multi-species KMT2A/MLL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KMT2A/MLL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a transcriptional coactivator that plays an essential role in regulating gene expression during early development and hematopoiesis. The encoded protein contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Multiple chromosomal translocations involving this gene are the cause of certain acute lymphoid leukemias and acute myeloid leukemias. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2010]
The Alternative Names of target: 6430520K01,ALL-1,ALL1,All1,CXXC-type zinc finger protein 7,CXXC7,Cxxc7,Cysteine methyltransferase KMT2A,GAS7,HRX,HTRX,HTRX1,Histone-lysine N-methyltransferase 2A,KMT2A,Kmt2a,Lysine N-methyltransferase 2A,MLL,MLL1,MLL1A,Mll,Mll1,Myeloid/lymphoid or mixed-lineage leukemia,Myeloid/lymphoid or mixed-lineage leukemia protein 1,TRX1,Trithorax-like protein,WDSTS,Zinc finger protein HRX,all-1,mKIAA4050

Target products collectionGo to KMT2A/MLL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T25462-Ag-1/ GM-Tg-hg-T25462-Ag-2 Human KMT2A/MLL protein Human
GM-Tg-rg-T25462-Ag-1/ GM-Tg-rg-T25462-Ag-2 Rat KMT2A/MLL protein Rat
GM-Tg-mg-T25462-Ag-1/ GM-Tg-mg-T25462-Ag-2 Mouse KMT2A/MLL protein Mouse
GM-Tg-cynog-T25462-Ag-1/ GM-Tg-cynog-T25462-Ag-2 Cynomolgus/Rhesus macaque KMT2A/MLL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T25462-Ag-1/ GM-Tg-felg-T25462-Ag-2 Feline KMT2A/MLL protein Feline
GM-Tg-cang-T25462-Ag-1/ GM-Tg-cang-T25462-Ag-2 Canine KMT2A/MLL protein Canine
GM-Tg-bovg-T25462-Ag-1/ GM-Tg-bovg-T25462-Ag-2 Bovine KMT2A/MLL protein Bovine
GM-Tg-equg-T25462-Ag-1/ GM-Tg-equg-T25462-Ag-2 Equine KMT2A/MLL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T25462-Ag-1/ GM-Tg-hg-T25462-Ag-2; GM-Tg-rg-T25462-Ag-1/ GM-Tg-rg-T25462-Ag-2;
GM-Tg-mg-T25462-Ag-1/ GM-Tg-mg-T25462-Ag-2; GM-Tg-cynog-T25462-Ag-1/ GM-Tg-cynog-T25462-Ag-2;
GM-Tg-felg-T25462-Ag-1/ GM-Tg-felg-T25462-Ag-2; GM-Tg-cang-T25462-Ag-1/ GM-Tg-cang-T25462-Ag-2;
GM-Tg-bovg-T25462-Ag-1/ GM-Tg-bovg-T25462-Ag-2; GM-Tg-equg-T25462-Ag-1/ GM-Tg-equg-T25462-Ag-2
Products Name KMT2A/MLL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name KMT2A/MLL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine KMT2A/MLL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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