Recombinant multi-species c-Cbl/CBL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine c-Cbl/CBL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia, and expansion of CGG repeats in the 5' UTR has been associated with Jacobsen syndrome. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Jul 2016]
The Alternative Names of target: 4732447J05Rik,C-CBL,CBL,CBL2,Casitas B-lineage lymphoma proto-oncogene,Cbl,Cbl-2,E3 ubiquitin-protein ligase CBL,FRA11B,NSLL,Proto-oncogene c-Cbl,RGD1561386,RING finger protein 55,RING-type E3 ubiquitin transferase CBL,RNF55,Signal transduction protein CBL,c-Cbl,c-cbl-like,cbl

Target products collectionGo to c-Cbl/CBL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T25309-Ag-1/ GM-Tg-hg-T25309-Ag-2 Human c-Cbl/CBL protein Human
GM-Tg-rg-T25309-Ag-1/ GM-Tg-rg-T25309-Ag-2 Rat c-Cbl/CBL protein Rat
GM-Tg-mg-T25309-Ag-1/ GM-Tg-mg-T25309-Ag-2 Mouse c-Cbl/CBL protein Mouse
GM-Tg-cynog-T25309-Ag-1/ GM-Tg-cynog-T25309-Ag-2 Cynomolgus/Rhesus macaque c-Cbl/CBL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T25309-Ag-1/ GM-Tg-felg-T25309-Ag-2 Feline c-Cbl/CBL protein Feline
GM-Tg-cang-T25309-Ag-1/ GM-Tg-cang-T25309-Ag-2 Canine c-Cbl/CBL protein Canine
GM-Tg-bovg-T25309-Ag-1/ GM-Tg-bovg-T25309-Ag-2 Bovine c-Cbl/CBL protein Bovine
GM-Tg-equg-T25309-Ag-1/ GM-Tg-equg-T25309-Ag-2 Equine c-Cbl/CBL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T25309-Ag-1/ GM-Tg-hg-T25309-Ag-2; GM-Tg-rg-T25309-Ag-1/ GM-Tg-rg-T25309-Ag-2;
GM-Tg-mg-T25309-Ag-1/ GM-Tg-mg-T25309-Ag-2; GM-Tg-cynog-T25309-Ag-1/ GM-Tg-cynog-T25309-Ag-2;
GM-Tg-felg-T25309-Ag-1/ GM-Tg-felg-T25309-Ag-2; GM-Tg-cang-T25309-Ag-1/ GM-Tg-cang-T25309-Ag-2;
GM-Tg-bovg-T25309-Ag-1/ GM-Tg-bovg-T25309-Ag-2; GM-Tg-equg-T25309-Ag-1/ GM-Tg-equg-T25309-Ag-2
Products Name c-Cbl/CBL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name c-Cbl/CBL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine c-Cbl/CBL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.