Recombinant multi-species GREM1/Gremlin-1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GREM1/Gremlin-1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
The Alternative Names of target: BMP antagonist 1,C15DUPq,CKTSF1B1,CRAC1,CRCS4,Cell proliferation-inducing gene 2 protein,Cktsf1b1,Cysteine knot superfamily 1,DAN domain family member 2,DAND2,DRM,DUP15q,Down-regulated in Mos-transformed cells protein,Drm,GREM1,GREMLIN,Grem,Grem1,Gremlin-1,HMPS,HMPS1,IHG-2,Increased in high glucose protein 2 (IHG-2),MPSH,PIG2,drm,gremlin-1,ld

Target products collectionGo to GREM1/Gremlin-1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T22104-Ag-1/ GM-Tg-hg-T22104-Ag-2 Human GREM1/Gremlin-1 protein Human
GM-Tg-rg-T22104-Ag-1/ GM-Tg-rg-T22104-Ag-2 Rat GREM1/Gremlin-1 protein Rat
GM-Tg-mg-T22104-Ag-1/ GM-Tg-mg-T22104-Ag-2 Mouse GREM1/Gremlin-1 protein Mouse
GM-Tg-cynog-T22104-Ag-1/ GM-Tg-cynog-T22104-Ag-2 Cynomolgus/Rhesus macaque GREM1/Gremlin-1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T22104-Ag-1/ GM-Tg-felg-T22104-Ag-2 Feline GREM1/Gremlin-1 protein Feline
GM-Tg-cang-T22104-Ag-1/ GM-Tg-cang-T22104-Ag-2 Canine GREM1/Gremlin-1 protein Canine
GM-Tg-bovg-T22104-Ag-1/ GM-Tg-bovg-T22104-Ag-2 Bovine GREM1/Gremlin-1 protein Bovine
GM-Tg-equg-T22104-Ag-1/ GM-Tg-equg-T22104-Ag-2 Equine GREM1/Gremlin-1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T22104-Ag-1/ GM-Tg-hg-T22104-Ag-2; GM-Tg-rg-T22104-Ag-1/ GM-Tg-rg-T22104-Ag-2;
GM-Tg-mg-T22104-Ag-1/ GM-Tg-mg-T22104-Ag-2; GM-Tg-cynog-T22104-Ag-1/ GM-Tg-cynog-T22104-Ag-2;
GM-Tg-felg-T22104-Ag-1/ GM-Tg-felg-T22104-Ag-2; GM-Tg-cang-T22104-Ag-1/ GM-Tg-cang-T22104-Ag-2;
GM-Tg-bovg-T22104-Ag-1/ GM-Tg-bovg-T22104-Ag-2; GM-Tg-equg-T22104-Ag-1/ GM-Tg-equg-T22104-Ag-2
Products Name GREM1/Gremlin-1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GREM1/Gremlin-1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GREM1/Gremlin-1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.