Recombinant multi-species IL-17A/IL17A/IL17 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-17A/IL17A/IL17 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]
The Alternative Names of target: CTLA-8,CTLA8,Ctla-8,Ctla8,Cytotoxic T-lymphocyte-associated antigen 8 (CTLA-8),IL-17,IL-17A,IL17,IL17A,ILA17,Il17,Il17a,Interleukin-17A

Target products collectionGo to IL-17A/IL17A/IL17 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T22095-Ag-1/ GM-Tg-hg-T22095-Ag-2 Human IL-17A/IL17A/IL17 protein Human
GM-Tg-rg-T22095-Ag-1/ GM-Tg-rg-T22095-Ag-2 Rat IL-17A/IL17A/IL17 protein Rat
GM-Tg-mg-T22095-Ag-1/ GM-Tg-mg-T22095-Ag-2 Mouse IL-17A/IL17A/IL17 protein Mouse
GM-Tg-cynog-T22095-Ag-1/ GM-Tg-cynog-T22095-Ag-2 Cynomolgus/Rhesus macaque IL-17A/IL17A/IL17 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T22095-Ag-1/ GM-Tg-felg-T22095-Ag-2 Feline IL-17A/IL17A/IL17 protein Feline
GM-Tg-cang-T22095-Ag-1/ GM-Tg-cang-T22095-Ag-2 Canine IL-17A/IL17A/IL17 protein Canine
GM-Tg-bovg-T22095-Ag-1/ GM-Tg-bovg-T22095-Ag-2 Bovine IL-17A/IL17A/IL17 protein Bovine
GM-Tg-equg-T22095-Ag-1/ GM-Tg-equg-T22095-Ag-2 Equine IL-17A/IL17A/IL17 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T22095-Ag-1/ GM-Tg-hg-T22095-Ag-2; GM-Tg-rg-T22095-Ag-1/ GM-Tg-rg-T22095-Ag-2;
GM-Tg-mg-T22095-Ag-1/ GM-Tg-mg-T22095-Ag-2; GM-Tg-cynog-T22095-Ag-1/ GM-Tg-cynog-T22095-Ag-2;
GM-Tg-felg-T22095-Ag-1/ GM-Tg-felg-T22095-Ag-2; GM-Tg-cang-T22095-Ag-1/ GM-Tg-cang-T22095-Ag-2;
GM-Tg-bovg-T22095-Ag-1/ GM-Tg-bovg-T22095-Ag-2; GM-Tg-equg-T22095-Ag-1/ GM-Tg-equg-T22095-Ag-2
Products Name IL-17A/IL17A/IL17 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-17A/IL17A/IL17
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-17A/IL17A/IL17 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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