Recombinant multi-species PCNA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PCNA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ATLD2,Cyclin,PCNA,PCNAR,Pcna,Pcna/cyclin,Proliferating cell nuclear antigen

Target products collectionGo to PCNA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T21782-Ag-1/ GM-Tg-hg-T21782-Ag-2 Human PCNA protein Human
GM-Tg-rg-T21782-Ag-1/ GM-Tg-rg-T21782-Ag-2 Rat PCNA protein Rat
GM-Tg-mg-T21782-Ag-1/ GM-Tg-mg-T21782-Ag-2 Mouse PCNA protein Mouse
GM-Tg-cynog-T21782-Ag-1/ GM-Tg-cynog-T21782-Ag-2 Cynomolgus/Rhesus macaque PCNA protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T21782-Ag-1/ GM-Tg-felg-T21782-Ag-2 Feline PCNA protein Feline
GM-Tg-cang-T21782-Ag-1/ GM-Tg-cang-T21782-Ag-2 Canine PCNA protein Canine
GM-Tg-bovg-T21782-Ag-1/ GM-Tg-bovg-T21782-Ag-2 Bovine PCNA protein Bovine
GM-Tg-equg-T21782-Ag-1/ GM-Tg-equg-T21782-Ag-2 Equine PCNA protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T21782-Ag-1/ GM-Tg-hg-T21782-Ag-2; GM-Tg-rg-T21782-Ag-1/ GM-Tg-rg-T21782-Ag-2;
GM-Tg-mg-T21782-Ag-1/ GM-Tg-mg-T21782-Ag-2; GM-Tg-cynog-T21782-Ag-1/ GM-Tg-cynog-T21782-Ag-2;
GM-Tg-felg-T21782-Ag-1/ GM-Tg-felg-T21782-Ag-2; GM-Tg-cang-T21782-Ag-1/ GM-Tg-cang-T21782-Ag-2;
GM-Tg-bovg-T21782-Ag-1/ GM-Tg-bovg-T21782-Ag-2; GM-Tg-equg-T21782-Ag-1/ GM-Tg-equg-T21782-Ag-2
Products Name PCNA protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PCNA
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PCNA protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.