Recombinant multi-species HP/Haptoglobin protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HP/Haptoglobin protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind free plasma hemoglobin, which allows degradative enzymes to gain access to the hemoglobin, while at the same time preventing loss of iron through the kidneys and protecting the kidneys from damage by hemoglobin. Mutations in this gene and/or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked to diabetic nephropathy, the incidence of coronary artery disease in type 1 diabetes, Crohn's disease, inflammatory disease behavior, primary sclerosing cholangitis, susceptibility to idiopathic Parkinson's disease, and a reduced incidence of Plasmodium falciparum malaria. The protein encoded also exhibits antimicrobial activity against bacteria. A similar duplicated gene is located next to this gene on chromosome 16. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2014]
The Alternative Names of target: BP,Ba1-647,HP,HP-1,HP2ALPHA2,HPA1S,Haptoglobin,Hp,Zonulin,preHP2

Target products collectionGo to HP/Haptoglobin products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T17710-Ag-1/ GM-Tg-hg-T17710-Ag-2 Human HP/Haptoglobin protein Human
GM-Tg-rg-T17710-Ag-1/ GM-Tg-rg-T17710-Ag-2 Rat HP/Haptoglobin protein Rat
GM-Tg-mg-T17710-Ag-1/ GM-Tg-mg-T17710-Ag-2 Mouse HP/Haptoglobin protein Mouse
GM-Tg-cynog-T17710-Ag-1/ GM-Tg-cynog-T17710-Ag-2 Cynomolgus/Rhesus macaque HP/Haptoglobin protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T17710-Ag-1/ GM-Tg-felg-T17710-Ag-2 Feline HP/Haptoglobin protein Feline
GM-Tg-cang-T17710-Ag-1/ GM-Tg-cang-T17710-Ag-2 Canine HP/Haptoglobin protein Canine
GM-Tg-bovg-T17710-Ag-1/ GM-Tg-bovg-T17710-Ag-2 Bovine HP/Haptoglobin protein Bovine
GM-Tg-equg-T17710-Ag-1/ GM-Tg-equg-T17710-Ag-2 Equine HP/Haptoglobin protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T17710-Ag-1/ GM-Tg-hg-T17710-Ag-2; GM-Tg-rg-T17710-Ag-1/ GM-Tg-rg-T17710-Ag-2;
GM-Tg-mg-T17710-Ag-1/ GM-Tg-mg-T17710-Ag-2; GM-Tg-cynog-T17710-Ag-1/ GM-Tg-cynog-T17710-Ag-2;
GM-Tg-felg-T17710-Ag-1/ GM-Tg-felg-T17710-Ag-2; GM-Tg-cang-T17710-Ag-1/ GM-Tg-cang-T17710-Ag-2;
GM-Tg-bovg-T17710-Ag-1/ GM-Tg-bovg-T17710-Ag-2; GM-Tg-equg-T17710-Ag-1/ GM-Tg-equg-T17710-Ag-2
Products Name HP/Haptoglobin protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HP/Haptoglobin
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HP/Haptoglobin protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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