Recombinant multi-species RPE65 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RPE65 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a component of the vitamin A visual cycle of the retina which supplies the 11-cis retinal chromophore of the photoreceptors opsin visual pigments. It is a member of the carotenoid cleavage oxygenase superfamily. All members of this superfamily are non-heme iron oxygenases with a seven-bladed propeller fold and oxidatively cleave carotenoid carbon:carbon double bonds. However, the protein encoded by this gene has acquired a divergent function that involves the concerted O-alkyl ester cleavage of its all-trans retinyl ester substrate and all-trans to 11-cis double bond isomerization of the retinyl moiety. As such, it performs the essential enzymatic isomerization step in the synthesis of 11-cis retinal. Mutations in this gene are associated with early-onset severe blinding disorders such as Leber congenital. [provided by RefSeq, Oct 2017]
The Alternative Names of target: 65kDa,A930029L06Rik,All-trans-retinyl-palmitate hydrolase,BCO3,LCA2,Lutein isomerase,Meso-zeaxanthin isomerase,Mord1,RP20,RPE65,Retinal pigment epithelium-specific 65 kDa protein,Retinoid isomerohydrolase,Retinol isomerase,Rpe65,mRPE65,p63,rd12,sRPE65

Target products collectionGo to RPE65 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T17502-Ag-1/ GM-Tg-hg-T17502-Ag-2 Human RPE65 protein Human
GM-Tg-rg-T17502-Ag-1/ GM-Tg-rg-T17502-Ag-2 Rat RPE65 protein Rat
GM-Tg-mg-T17502-Ag-1/ GM-Tg-mg-T17502-Ag-2 Mouse RPE65 protein Mouse
GM-Tg-cynog-T17502-Ag-1/ GM-Tg-cynog-T17502-Ag-2 Cynomolgus/Rhesus macaque RPE65 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T17502-Ag-1/ GM-Tg-felg-T17502-Ag-2 Feline RPE65 protein Feline
GM-Tg-cang-T17502-Ag-1/ GM-Tg-cang-T17502-Ag-2 Canine RPE65 protein Canine
GM-Tg-bovg-T17502-Ag-1/ GM-Tg-bovg-T17502-Ag-2 Bovine RPE65 protein Bovine
GM-Tg-equg-T17502-Ag-1/ GM-Tg-equg-T17502-Ag-2 Equine RPE65 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T17502-Ag-1/ GM-Tg-hg-T17502-Ag-2; GM-Tg-rg-T17502-Ag-1/ GM-Tg-rg-T17502-Ag-2;
GM-Tg-mg-T17502-Ag-1/ GM-Tg-mg-T17502-Ag-2; GM-Tg-cynog-T17502-Ag-1/ GM-Tg-cynog-T17502-Ag-2;
GM-Tg-felg-T17502-Ag-1/ GM-Tg-felg-T17502-Ag-2; GM-Tg-cang-T17502-Ag-1/ GM-Tg-cang-T17502-Ag-2;
GM-Tg-bovg-T17502-Ag-1/ GM-Tg-bovg-T17502-Ag-2; GM-Tg-equg-T17502-Ag-1/ GM-Tg-equg-T17502-Ag-2
Products Name RPE65 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RPE65
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RPE65 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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