Recombinant multi-species TOP2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TOP2A protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
The Alternative Names of target: DNA topoisomerase 2-alpha,DNA topoisomerase II,TOP2,TOP2A,TOP2alpha,TOPIIA,TP2A,Top-2,Top2a,alpha isozyme

Target products collectionGo to TOP2A products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T17048-Ag-1/ GM-Tg-hg-T17048-Ag-2 Human TOP2A protein Human
GM-Tg-rg-T17048-Ag-1/ GM-Tg-rg-T17048-Ag-2 Rat TOP2A protein Rat
GM-Tg-mg-T17048-Ag-1/ GM-Tg-mg-T17048-Ag-2 Mouse TOP2A protein Mouse
GM-Tg-cynog-T17048-Ag-1/ GM-Tg-cynog-T17048-Ag-2 Cynomolgus/Rhesus macaque TOP2A protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T17048-Ag-1/ GM-Tg-felg-T17048-Ag-2 Feline TOP2A protein Feline
GM-Tg-cang-T17048-Ag-1/ GM-Tg-cang-T17048-Ag-2 Canine TOP2A protein Canine
GM-Tg-bovg-T17048-Ag-1/ GM-Tg-bovg-T17048-Ag-2 Bovine TOP2A protein Bovine
GM-Tg-equg-T17048-Ag-1/ GM-Tg-equg-T17048-Ag-2 Equine TOP2A protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T17048-Ag-1/ GM-Tg-hg-T17048-Ag-2; GM-Tg-rg-T17048-Ag-1/ GM-Tg-rg-T17048-Ag-2;
GM-Tg-mg-T17048-Ag-1/ GM-Tg-mg-T17048-Ag-2; GM-Tg-cynog-T17048-Ag-1/ GM-Tg-cynog-T17048-Ag-2;
GM-Tg-felg-T17048-Ag-1/ GM-Tg-felg-T17048-Ag-2; GM-Tg-cang-T17048-Ag-1/ GM-Tg-cang-T17048-Ag-2;
GM-Tg-bovg-T17048-Ag-1/ GM-Tg-bovg-T17048-Ag-2; GM-Tg-equg-T17048-Ag-1/ GM-Tg-equg-T17048-Ag-2
Products Name TOP2A protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name TOP2A
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine TOP2A protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.