Recombinant multi-species BRCA2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BRCA2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Inherited mutations in BRCA1 and this gene, BRCA2, confer increased lifetime risk of developing breast or ovarian cancer. Both BRCA1 and BRCA2 are involved in maintenance of genome stability, specifically the homologous recombination pathway for double-strand DNA repair. The largest exon in both genes is exon 11, which harbors the most important and frequent mutations in breast cancer patients. The BRCA2 gene was found on chromosome 13q12.3 in human. The BRCA2 protein contains several copies of a 70 aa motif called the BRC motif, and these motifs mediate binding to the RAD51 recombinase which functions in DNA repair. BRCA2 is considered a tumor suppressor gene, as tumors with BRCA2 mutations generally exhibit loss of heterozygosity (LOH) of the wild-type allele. [provided by RefSeq, May 2020]
The Alternative Names of target: BRCA2,BRCC2,BROVCA2,Brca2,Breast cancer type 2 susceptibility protein,FACD,FAD,FAD1,FANCD,FANCD1,Fancd1,Fanconi anemia group D1 protein,GLM3,PNCA2,RAB163,XRCC11

Target products collectionGo to BRCA2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T15823-Ag-1/ GM-Tg-hg-T15823-Ag-2 Human BRCA2 protein Human
GM-Tg-rg-T15823-Ag-1/ GM-Tg-rg-T15823-Ag-2 Rat BRCA2 protein Rat
GM-Tg-mg-T15823-Ag-1/ GM-Tg-mg-T15823-Ag-2 Mouse BRCA2 protein Mouse
GM-Tg-cynog-T15823-Ag-1/ GM-Tg-cynog-T15823-Ag-2 Cynomolgus/Rhesus macaque BRCA2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T15823-Ag-1/ GM-Tg-felg-T15823-Ag-2 Feline BRCA2 protein Feline
GM-Tg-cang-T15823-Ag-1/ GM-Tg-cang-T15823-Ag-2 Canine BRCA2 protein Canine
GM-Tg-bovg-T15823-Ag-1/ GM-Tg-bovg-T15823-Ag-2 Bovine BRCA2 protein Bovine
GM-Tg-equg-T15823-Ag-1/ GM-Tg-equg-T15823-Ag-2 Equine BRCA2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T15823-Ag-1/ GM-Tg-hg-T15823-Ag-2; GM-Tg-rg-T15823-Ag-1/ GM-Tg-rg-T15823-Ag-2;
GM-Tg-mg-T15823-Ag-1/ GM-Tg-mg-T15823-Ag-2; GM-Tg-cynog-T15823-Ag-1/ GM-Tg-cynog-T15823-Ag-2;
GM-Tg-felg-T15823-Ag-1/ GM-Tg-felg-T15823-Ag-2; GM-Tg-cang-T15823-Ag-1/ GM-Tg-cang-T15823-Ag-2;
GM-Tg-bovg-T15823-Ag-1/ GM-Tg-bovg-T15823-Ag-2; GM-Tg-equg-T15823-Ag-1/ GM-Tg-equg-T15823-Ag-2
Products Name BRCA2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BRCA2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BRCA2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.