Recombinant multi-species HMGB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGB2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles.  These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]
The Alternative Names of target: HMGB2,High mobility group protein B2,High mobility group protein 2 (HMG-2),HMG2

Target products collectionGo to HMGB2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T12974-Ab-1/ GM-Tg-hg-T12974-Ab-2 Human HMGB2 protein Human
GM-Tg-rg-T12974-Ab-1/ GM-Tg-rg-T12974-Ab-2 Rat HMGB2 protein Rat
GM-Tg-mg-T12974-Ab-1/ GM-Tg-mg-T12974-Ab-2 Mouse HMGB2 protein Mouse
GM-Tg-cynog-T12974-Ab-1/ GM-Tg-cynog-T12974-Ab-2 Cynomolgus/Rhesus macaque HMGB2 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-T12974-Ab-1/ GM-Tg-felg-T12974-Ab-2 Feline HMGB2 protein Feline
GM-Tg-cang-T12974-Ab-1/ GM-Tg-cang-T12974-Ab-2 Canine HMGB2 protein Canine
GM-Tg-bovg-T12974-Ab-1/ GM-Tg-bovg-T12974-Ab-2 Bovine HMGB2 protein Bovine
GM-Tg-equg-T12974-Ab-1/ GM-Tg-equg-T12974-Ab-2 Equine HMGB2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T12974-Ab-1/ GM-Tg-hg-T12974-Ab-2; GM-Tg-rg-T12974-Ab-1/ GM-Tg-rg-T12974-Ab-2;
GM-Tg-mg-T12974-Ab-1/ GM-Tg-mg-T12974-Ab-2; GM-Tg-cynog-T12974-Ab-1/ GM-Tg-cynog-T12974-Ab-2;
GM-Tg-felg-T12974-Ab-1/ GM-Tg-felg-T12974-Ab-2; GM-Tg-cang-T12974-Ab-1/ GM-Tg-cang-T12974-Ab-2;
GM-Tg-bovg-T12974-Ab-1/ GM-Tg-bovg-T12974-Ab-2; GM-Tg-equg-T12974-Ab-1/ GM-Tg-equg-T12974-Ab-2
Products Name HMGB2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name HMGB2
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine HMGB2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.