Recombinant multi-species BCL2A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL2A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and is up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The Alternative Names of target: ACC-1,ACC-2,ACC1,ACC2,BCL2A1,BCL2L5,BFL1,Bcl-2-like protein 5 (Bcl2-L-5),Bcl-2-related protein A1,Bcl2a1,Bcl2a1d,GRS,HBPA1,Hemopoietic-specific early response protein,Protein BFL-1,Protein GRS

Target products collectionGo to BCL2A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T12797-Ag-1/ GM-Tg-hg-T12797-Ag-2 Human BCL2A1 protein Human
GM-Tg-rg-T12797-Ag-1/ GM-Tg-rg-T12797-Ag-2 Rat BCL2A1 protein Rat
GM-Tg-mg-T12797-Ag-1/ GM-Tg-mg-T12797-Ag-2 Mouse BCL2A1 protein Mouse
GM-Tg-cynog-T12797-Ag-1/ GM-Tg-cynog-T12797-Ag-2 Cynomolgus/Rhesus macaque BCL2A1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T12797-Ag-1/ GM-Tg-felg-T12797-Ag-2 Feline BCL2A1 protein Feline
GM-Tg-cang-T12797-Ag-1/ GM-Tg-cang-T12797-Ag-2 Canine BCL2A1 protein Canine
GM-Tg-bovg-T12797-Ag-1/ GM-Tg-bovg-T12797-Ag-2 Bovine BCL2A1 protein Bovine
GM-Tg-equg-T12797-Ag-1/ GM-Tg-equg-T12797-Ag-2 Equine BCL2A1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T12797-Ag-1/ GM-Tg-hg-T12797-Ag-2; GM-Tg-rg-T12797-Ag-1/ GM-Tg-rg-T12797-Ag-2;
GM-Tg-mg-T12797-Ag-1/ GM-Tg-mg-T12797-Ag-2; GM-Tg-cynog-T12797-Ag-1/ GM-Tg-cynog-T12797-Ag-2;
GM-Tg-felg-T12797-Ag-1/ GM-Tg-felg-T12797-Ag-2; GM-Tg-cang-T12797-Ag-1/ GM-Tg-cang-T12797-Ag-2;
GM-Tg-bovg-T12797-Ag-1/ GM-Tg-bovg-T12797-Ag-2; GM-Tg-equg-T12797-Ag-1/ GM-Tg-equg-T12797-Ag-2
Products Name BCL2A1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name BCL2A1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine BCL2A1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.