Recombinant multi-species Caspase 2/p32/p18/CASP2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Caspase 2/p32/p18/CASP2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
The Alternative Names of target: CASP-2,CASP2,Casp2,Caspase 2,Caspase-2,ICH-1,ICH1,MRT80,NEDD-2,NEDD2,Nedd2,Neural precursor cell expressed developmentally down-regulated protein 2 (NEDD-2),PPP1R57,Protease ICH-1,p18,p32

Target products collectionGo to Caspase 2/p32/p18/CASP2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T09128-Ag-1/ GM-Tg-hg-T09128-Ag-2 Human Caspase 2/p32/p18/CASP2 protein Human
GM-Tg-rg-T09128-Ag-1/ GM-Tg-rg-T09128-Ag-2 Rat Caspase 2/p32/p18/CASP2 protein Rat
GM-Tg-mg-T09128-Ag-1/ GM-Tg-mg-T09128-Ag-2 Mouse Caspase 2/p32/p18/CASP2 protein Mouse
GM-Tg-cynog-T09128-Ag-1/ GM-Tg-cynog-T09128-Ag-2 Cynomolgus/Rhesus macaque Caspase 2/p32/p18/CASP2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T09128-Ag-1/ GM-Tg-felg-T09128-Ag-2 Feline Caspase 2/p32/p18/CASP2 protein Feline
GM-Tg-cang-T09128-Ag-1/ GM-Tg-cang-T09128-Ag-2 Canine Caspase 2/p32/p18/CASP2 protein Canine
GM-Tg-bovg-T09128-Ag-1/ GM-Tg-bovg-T09128-Ag-2 Bovine Caspase 2/p32/p18/CASP2 protein Bovine
GM-Tg-equg-T09128-Ag-1/ GM-Tg-equg-T09128-Ag-2 Equine Caspase 2/p32/p18/CASP2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T09128-Ag-1/ GM-Tg-hg-T09128-Ag-2; GM-Tg-rg-T09128-Ag-1/ GM-Tg-rg-T09128-Ag-2;
GM-Tg-mg-T09128-Ag-1/ GM-Tg-mg-T09128-Ag-2; GM-Tg-cynog-T09128-Ag-1/ GM-Tg-cynog-T09128-Ag-2;
GM-Tg-felg-T09128-Ag-1/ GM-Tg-felg-T09128-Ag-2; GM-Tg-cang-T09128-Ag-1/ GM-Tg-cang-T09128-Ag-2;
GM-Tg-bovg-T09128-Ag-1/ GM-Tg-bovg-T09128-Ag-2; GM-Tg-equg-T09128-Ag-1/ GM-Tg-equg-T09128-Ag-2
Products Name Caspase 2/p32/p18/CASP2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Caspase 2/p32/p18/CASP2
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Caspase 2/p32/p18/CASP2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.