Recombinant multi-species CSK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CSK protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
The Alternative Names of target: C-Src kinase,CSK,Csk,Protein-tyrosine kinase CYL,Tyrosine-protein kinase CSK,p50CSK

Target products collectionGo to CSK products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T08741-Ag-1/ GM-Tg-hg-T08741-Ag-2 Human CSK protein Human
GM-Tg-rg-T08741-Ag-1/ GM-Tg-rg-T08741-Ag-2 Rat CSK protein Rat
GM-Tg-mg-T08741-Ag-1/ GM-Tg-mg-T08741-Ag-2 Mouse CSK protein Mouse
GM-Tg-cynog-T08741-Ag-1/ GM-Tg-cynog-T08741-Ag-2 Cynomolgus/Rhesus macaque CSK protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T08741-Ag-1/ GM-Tg-felg-T08741-Ag-2 Feline CSK protein Feline
GM-Tg-cang-T08741-Ag-1/ GM-Tg-cang-T08741-Ag-2 Canine CSK protein Canine
GM-Tg-bovg-T08741-Ag-1/ GM-Tg-bovg-T08741-Ag-2 Bovine CSK protein Bovine
GM-Tg-equg-T08741-Ag-1/ GM-Tg-equg-T08741-Ag-2 Equine CSK protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T08741-Ag-1/ GM-Tg-hg-T08741-Ag-2; GM-Tg-rg-T08741-Ag-1/ GM-Tg-rg-T08741-Ag-2;
GM-Tg-mg-T08741-Ag-1/ GM-Tg-mg-T08741-Ag-2; GM-Tg-cynog-T08741-Ag-1/ GM-Tg-cynog-T08741-Ag-2;
GM-Tg-felg-T08741-Ag-1/ GM-Tg-felg-T08741-Ag-2; GM-Tg-cang-T08741-Ag-1/ GM-Tg-cang-T08741-Ag-2;
GM-Tg-bovg-T08741-Ag-1/ GM-Tg-bovg-T08741-Ag-2; GM-Tg-equg-T08741-Ag-1/ GM-Tg-equg-T08741-Ag-2
Products Name CSK protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CSK
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CSK protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.