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Recombinant multi-species IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
The Alternative Names of target: IL-23,IL-23 p19,IL-23 subunit alpha,IL-23-A,IL-23A,IL23,IL23A,IL23P19,Il23a,Interleukin-23 subunit alpha,Interleukin-23 subunit p19 (IL-23p19),NeutraControl IL-23 p19,P19,SGRF,p19
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MSDSProduct information
| Catalog No. | Product Name | Species Reactivity |
|---|---|---|
| GM-Tg-hg-T06841-Ag-1/ GM-Tg-hg-T06841-Ag-2 | Human IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Human |
| GM-Tg-rg-T06841-Ag-1/ GM-Tg-rg-T06841-Ag-2 | Rat IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Rat |
| GM-Tg-mg-T06841-Ag-1/ GM-Tg-mg-T06841-Ag-2 | Mouse IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Mouse |
| GM-Tg-cynog-T06841-Ag-1/ GM-Tg-cynog-T06841-Ag-2 | Cynomolgus/Rhesus macaque IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Cynomolgus/ Rhesus macaque |
| GM-Tg-felg-T06841-Ag-1/ GM-Tg-felg-T06841-Ag-2 | Feline IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Feline |
| GM-Tg-cang-T06841-Ag-1/ GM-Tg-cang-T06841-Ag-2 | Canine IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Canine |
| GM-Tg-bovg-T06841-Ag-1/ GM-Tg-bovg-T06841-Ag-2 | Bovine IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Bovine |
| GM-Tg-equg-T06841-Ag-1/ GM-Tg-equg-T06841-Ag-2 | Equine IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein | Equine |
Size： 1mg | 10mg | 100mg
Product Description
| Catalog No. |
GM-Tg-hg-T06841-Ag-1/ GM-Tg-hg-T06841-Ag-2;
GM-Tg-rg-T06841-Ag-1/ GM-Tg-rg-T06841-Ag-2;
GM-Tg-mg-T06841-Ag-1/ GM-Tg-mg-T06841-Ag-2; GM-Tg-cynog-T06841-Ag-1/ GM-Tg-cynog-T06841-Ag-2; GM-Tg-felg-T06841-Ag-1/ GM-Tg-felg-T06841-Ag-2; GM-Tg-cang-T06841-Ag-1/ GM-Tg-cang-T06841-Ag-2; GM-Tg-bovg-T06841-Ag-1/ GM-Tg-bovg-T06841-Ag-2; GM-Tg-equg-T06841-Ag-1/ GM-Tg-equg-T06841-Ag-2 |
| Products Name | IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein |
| Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
| Target Name | IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 |
| Protein Sub-location | Secreted Protein/Potential Cytokines |
| Isotypes | Recombinant protein |
| Expression platform | Mammalian cell |
| Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
| Tag | His |
| Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-23 p19/NeutraControl IL-23 p19/IL23A/IL23 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
| Purity | Purity: ≥95% (SDS-PAGE) |
| Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
| Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
| Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.