Recombinant multi-species CREBBP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CREBBP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009]
The Alternative Names of target: CBP,CBP/p300,CREB-binding protein,CREBBP,Crebbp,Histone lysine acetyltransferase CREBBP,KAT3A,MKHK1,Protein lactyltransferas CREBBP,Protein-lysine acetyltransferase CREBBP,RSTS,RSTS1,RTS,hmm291030,p300/CBP

Target products collectionGo to CREBBP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T03634-Ag-1/ GM-Tg-hg-T03634-Ag-2 Human CREBBP protein Human
GM-Tg-rg-T03634-Ag-1/ GM-Tg-rg-T03634-Ag-2 Rat CREBBP protein Rat
GM-Tg-mg-T03634-Ag-1/ GM-Tg-mg-T03634-Ag-2 Mouse CREBBP protein Mouse
GM-Tg-cynog-T03634-Ag-1/ GM-Tg-cynog-T03634-Ag-2 Cynomolgus/Rhesus macaque CREBBP protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T03634-Ag-1/ GM-Tg-felg-T03634-Ag-2 Feline CREBBP protein Feline
GM-Tg-cang-T03634-Ag-1/ GM-Tg-cang-T03634-Ag-2 Canine CREBBP protein Canine
GM-Tg-bovg-T03634-Ag-1/ GM-Tg-bovg-T03634-Ag-2 Bovine CREBBP protein Bovine
GM-Tg-equg-T03634-Ag-1/ GM-Tg-equg-T03634-Ag-2 Equine CREBBP protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T03634-Ag-1/ GM-Tg-hg-T03634-Ag-2; GM-Tg-rg-T03634-Ag-1/ GM-Tg-rg-T03634-Ag-2;
GM-Tg-mg-T03634-Ag-1/ GM-Tg-mg-T03634-Ag-2; GM-Tg-cynog-T03634-Ag-1/ GM-Tg-cynog-T03634-Ag-2;
GM-Tg-felg-T03634-Ag-1/ GM-Tg-felg-T03634-Ag-2; GM-Tg-cang-T03634-Ag-1/ GM-Tg-cang-T03634-Ag-2;
GM-Tg-bovg-T03634-Ag-1/ GM-Tg-bovg-T03634-Ag-2; GM-Tg-equg-T03634-Ag-1/ GM-Tg-equg-T03634-Ag-2
Products Name CREBBP protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CREBBP
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CREBBP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.