Recombinant multi-species PIP5K3/PIKFYVE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PIP5K3/PIKFYVE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. The protein plays a key role in cell entry of ebola virus and SARS-CoV-2 by endocytosis Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. [provided by RefSeq, Jul 2021]
The Alternative Names of target: 1-phosphatidylinositol 3-phosphate 5-kinase,5230400C17Rik,CFD,FAB1,FYVE finger-containing phosphoinositide kinase,HEL37,PIKFYVE,PIKfyve,PIP5K,PIP5K3,Phosphatidylinositol 3-phosphate 5-kinase,Phosphatidylinositol 3-phosphate 5-kinase type III (PIPkin-III,Pikfyve,Pip5k,Pip5k3,Pipk5k3,PipkIII,Serine-protein kinase PIKFYVE,Type III PIP kinase),ZFYVE29,fab1-like,p235

Target products collectionGo to PIP5K3/PIKFYVE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T02469-Ag-1/ GM-Tg-hg-T02469-Ag-2 Human PIP5K3/PIKFYVE protein Human
GM-Tg-rg-T02469-Ag-1/ GM-Tg-rg-T02469-Ag-2 Rat PIP5K3/PIKFYVE protein Rat
GM-Tg-mg-T02469-Ag-1/ GM-Tg-mg-T02469-Ag-2 Mouse PIP5K3/PIKFYVE protein Mouse
GM-Tg-cynog-T02469-Ag-1/ GM-Tg-cynog-T02469-Ag-2 Cynomolgus/Rhesus macaque PIP5K3/PIKFYVE protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T02469-Ag-1/ GM-Tg-felg-T02469-Ag-2 Feline PIP5K3/PIKFYVE protein Feline
GM-Tg-cang-T02469-Ag-1/ GM-Tg-cang-T02469-Ag-2 Canine PIP5K3/PIKFYVE protein Canine
GM-Tg-bovg-T02469-Ag-1/ GM-Tg-bovg-T02469-Ag-2 Bovine PIP5K3/PIKFYVE protein Bovine
GM-Tg-equg-T02469-Ag-1/ GM-Tg-equg-T02469-Ag-2 Equine PIP5K3/PIKFYVE protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T02469-Ag-1/ GM-Tg-hg-T02469-Ag-2; GM-Tg-rg-T02469-Ag-1/ GM-Tg-rg-T02469-Ag-2;
GM-Tg-mg-T02469-Ag-1/ GM-Tg-mg-T02469-Ag-2; GM-Tg-cynog-T02469-Ag-1/ GM-Tg-cynog-T02469-Ag-2;
GM-Tg-felg-T02469-Ag-1/ GM-Tg-felg-T02469-Ag-2; GM-Tg-cang-T02469-Ag-1/ GM-Tg-cang-T02469-Ag-2;
GM-Tg-bovg-T02469-Ag-1/ GM-Tg-bovg-T02469-Ag-2; GM-Tg-equg-T02469-Ag-1/ GM-Tg-equg-T02469-Ag-2
Products Name PIP5K3/PIKFYVE protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PIP5K3/PIKFYVE
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PIP5K3/PIKFYVE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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