Recombinant multi-species PML protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PML protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The Alternative Names of target: 1200009E24Rik,E3 SUMO-protein ligase PML,MYL,PML,PP8675,Pml,Promyelocytic leukemia protein,Protein PML,RGD1562602,RING finger protein 71,RING-type E3 SUMO transferase PML,RNF71,TRIM19,Trim19,Tripartite motif-containing protein 19 (TRIM19)

Target products collectionGo to PML products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T01683-Ag-1/ GM-Tg-hg-T01683-Ag-2 Human PML protein Human
GM-Tg-rg-T01683-Ag-1/ GM-Tg-rg-T01683-Ag-2 Rat PML protein Rat
GM-Tg-mg-T01683-Ag-1/ GM-Tg-mg-T01683-Ag-2 Mouse PML protein Mouse
GM-Tg-cynog-T01683-Ag-1/ GM-Tg-cynog-T01683-Ag-2 Cynomolgus/Rhesus macaque PML protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T01683-Ag-1/ GM-Tg-felg-T01683-Ag-2 Feline PML protein Feline
GM-Tg-cang-T01683-Ag-1/ GM-Tg-cang-T01683-Ag-2 Canine PML protein Canine
GM-Tg-bovg-T01683-Ag-1/ GM-Tg-bovg-T01683-Ag-2 Bovine PML protein Bovine
GM-Tg-equg-T01683-Ag-1/ GM-Tg-equg-T01683-Ag-2 Equine PML protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T01683-Ag-1/ GM-Tg-hg-T01683-Ag-2; GM-Tg-rg-T01683-Ag-1/ GM-Tg-rg-T01683-Ag-2;
GM-Tg-mg-T01683-Ag-1/ GM-Tg-mg-T01683-Ag-2; GM-Tg-cynog-T01683-Ag-1/ GM-Tg-cynog-T01683-Ag-2;
GM-Tg-felg-T01683-Ag-1/ GM-Tg-felg-T01683-Ag-2; GM-Tg-cang-T01683-Ag-1/ GM-Tg-cang-T01683-Ag-2;
GM-Tg-bovg-T01683-Ag-1/ GM-Tg-bovg-T01683-Ag-2; GM-Tg-equg-T01683-Ag-1/ GM-Tg-equg-T01683-Ag-2
Products Name PML protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PML
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PML protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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