Recombinant multi-species ABL T315I protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABL T315I protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
The Alternative Names of target: ABL,ABL T315I,ABL1,Abelson murine leukemia viral oncogene homolog 1,Abelson tyrosine-protein kinase 1,Abl,Abl1,BCR-ABL,CHDSKM,E430008G22Rik,JTK7,Proto-oncogene c-Abl,Tyrosine-protein kinase ABL1,bcr/abl,c-ABL,c-ABL1,c-Abl,p150,v-abl

Target products collectionGo to ABL T315I products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T00348-Ag-1/ GM-Tg-hg-T00348-Ag-2 Human ABL T315I protein Human
GM-Tg-rg-T00348-Ag-1/ GM-Tg-rg-T00348-Ag-2 Rat ABL T315I protein Rat
GM-Tg-mg-T00348-Ag-1/ GM-Tg-mg-T00348-Ag-2 Mouse ABL T315I protein Mouse
GM-Tg-cynog-T00348-Ag-1/ GM-Tg-cynog-T00348-Ag-2 Cynomolgus/Rhesus macaque ABL T315I protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T00348-Ag-1/ GM-Tg-felg-T00348-Ag-2 Feline ABL T315I protein Feline
GM-Tg-cang-T00348-Ag-1/ GM-Tg-cang-T00348-Ag-2 Canine ABL T315I protein Canine
GM-Tg-bovg-T00348-Ag-1/ GM-Tg-bovg-T00348-Ag-2 Bovine ABL T315I protein Bovine
GM-Tg-equg-T00348-Ag-1/ GM-Tg-equg-T00348-Ag-2 Equine ABL T315I protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T00348-Ag-1/ GM-Tg-hg-T00348-Ag-2; GM-Tg-rg-T00348-Ag-1/ GM-Tg-rg-T00348-Ag-2;
GM-Tg-mg-T00348-Ag-1/ GM-Tg-mg-T00348-Ag-2; GM-Tg-cynog-T00348-Ag-1/ GM-Tg-cynog-T00348-Ag-2;
GM-Tg-felg-T00348-Ag-1/ GM-Tg-felg-T00348-Ag-2; GM-Tg-cang-T00348-Ag-1/ GM-Tg-cang-T00348-Ag-2;
GM-Tg-bovg-T00348-Ag-1/ GM-Tg-bovg-T00348-Ag-2; GM-Tg-equg-T00348-Ag-1/ GM-Tg-equg-T00348-Ag-2
Products Name ABL T315I protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ABL T315I
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ABL T315I protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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