Recombinant multi-species IL-4/IL4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-4/IL4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
The Alternative Names of target: B-cell stimulatory factor 1 (BSF-1),BCGF-1,BCGF1,BSF-1,BSF1,Binetrakin,IL-4,IL4,Il-4,Il4,Il4e12,Interleukin-4,Lymphocyte stimulatory factor 1,Pitrakinra

Target products collectionGo to IL-4/IL4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-T00239-Ag-1/ GM-Tg-hg-T00239-Ag-2 Human IL-4/IL4 protein Human
GM-Tg-rg-T00239-Ag-1/ GM-Tg-rg-T00239-Ag-2 Rat IL-4/IL4 protein Rat
GM-Tg-mg-T00239-Ag-1/ GM-Tg-mg-T00239-Ag-2 Mouse IL-4/IL4 protein Mouse
GM-Tg-cynog-T00239-Ag-1/ GM-Tg-cynog-T00239-Ag-2 Cynomolgus/Rhesus macaque IL-4/IL4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-T00239-Ag-1/ GM-Tg-felg-T00239-Ag-2 Feline IL-4/IL4 protein Feline
GM-Tg-cang-T00239-Ag-1/ GM-Tg-cang-T00239-Ag-2 Canine IL-4/IL4 protein Canine
GM-Tg-bovg-T00239-Ag-1/ GM-Tg-bovg-T00239-Ag-2 Bovine IL-4/IL4 protein Bovine
GM-Tg-equg-T00239-Ag-1/ GM-Tg-equg-T00239-Ag-2 Equine IL-4/IL4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-T00239-Ag-1/ GM-Tg-hg-T00239-Ag-2; GM-Tg-rg-T00239-Ag-1/ GM-Tg-rg-T00239-Ag-2;
GM-Tg-mg-T00239-Ag-1/ GM-Tg-mg-T00239-Ag-2; GM-Tg-cynog-T00239-Ag-1/ GM-Tg-cynog-T00239-Ag-2;
GM-Tg-felg-T00239-Ag-1/ GM-Tg-felg-T00239-Ag-2; GM-Tg-cang-T00239-Ag-1/ GM-Tg-cang-T00239-Ag-2;
GM-Tg-bovg-T00239-Ag-1/ GM-Tg-bovg-T00239-Ag-2; GM-Tg-equg-T00239-Ag-1/ GM-Tg-equg-T00239-Ag-2
Products Name IL-4/IL4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name IL-4/IL4
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine IL-4/IL4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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