Recombinant multi-species GPX4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GPX4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development; thus, it has been identified as a 'moonlighting' protein because of its ability to serve dual functions as a peroxidase, as well as a structural protein in mature spermatozoa. Mutations in this gene are associated with Sedaghatian type of spondylometaphyseal dysplasia (SMDS). This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Transcript variants resulting from alternative splicing or use of alternate promoters have been described to encode isoforms with different subcellular localization. [provided by RefSeq, Dec 2018]
The Alternative Names of target: GPX4,GPx-4,GSHPx-4,GSHPx-4),Glutathione peroxidase 4 (GPx-4,Gpx4,Gshpx-4,MCSP,PHGPx,Phgpx,Phospholipid hydroperoxide glutathione peroxidase GPX4,SMDS,gpx-4,mtPHGPx,snGPx,snGpx,snPHGPx

Target products collectionGo to GPX4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1581-Ag-1/ GM-Tg-hg-SE1581-Ag-2 Human GPX4 protein Human
GM-Tg-rg-SE1581-Ag-1/ GM-Tg-rg-SE1581-Ag-2 Rat GPX4 protein Rat
GM-Tg-mg-SE1581-Ag-1/ GM-Tg-mg-SE1581-Ag-2 Mouse GPX4 protein Mouse
GM-Tg-cynog-SE1581-Ag-1/ GM-Tg-cynog-SE1581-Ag-2 Cynomolgus/Rhesus macaque GPX4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1581-Ag-1/ GM-Tg-felg-SE1581-Ag-2 Feline GPX4 protein Feline
GM-Tg-cang-SE1581-Ag-1/ GM-Tg-cang-SE1581-Ag-2 Canine GPX4 protein Canine
GM-Tg-bovg-SE1581-Ag-1/ GM-Tg-bovg-SE1581-Ag-2 Bovine GPX4 protein Bovine
GM-Tg-equg-SE1581-Ag-1/ GM-Tg-equg-SE1581-Ag-2 Equine GPX4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1581-Ag-1/ GM-Tg-hg-SE1581-Ag-2; GM-Tg-rg-SE1581-Ag-1/ GM-Tg-rg-SE1581-Ag-2;
GM-Tg-mg-SE1581-Ag-1/ GM-Tg-mg-SE1581-Ag-2; GM-Tg-cynog-SE1581-Ag-1/ GM-Tg-cynog-SE1581-Ag-2;
GM-Tg-felg-SE1581-Ag-1/ GM-Tg-felg-SE1581-Ag-2; GM-Tg-cang-SE1581-Ag-1/ GM-Tg-cang-SE1581-Ag-2;
GM-Tg-bovg-SE1581-Ag-1/ GM-Tg-bovg-SE1581-Ag-2; GM-Tg-equg-SE1581-Ag-1/ GM-Tg-equg-SE1581-Ag-2
Products Name GPX4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name GPX4
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine GPX4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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