Recombinant multi-species C9orf72 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine C9orf72 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016]
The Alternative Names of target: 3110043O21Rik,ALSFTD,C11H9orf72,C15H9orf72,C23H9orf72,C8H9orf72,C9orf72,CD4H9orf72,DENND9,DENNL72,Dennd9,FTDALS,FTDALS1,Guanine nucleotide exchange factor C9orf72,RGD1359108

Target products collectionGo to C9orf72 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1533-Ag-1/ GM-Tg-hg-SE1533-Ag-2 Human C9orf72 protein Human
GM-Tg-rg-SE1533-Ag-1/ GM-Tg-rg-SE1533-Ag-2 Rat C9orf72 protein Rat
GM-Tg-mg-SE1533-Ag-1/ GM-Tg-mg-SE1533-Ag-2 Mouse C9orf72 protein Mouse
GM-Tg-cynog-SE1533-Ag-1/ GM-Tg-cynog-SE1533-Ag-2 Cynomolgus/Rhesus macaque C9orf72 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1533-Ag-1/ GM-Tg-felg-SE1533-Ag-2 Feline C9orf72 protein Feline
GM-Tg-cang-SE1533-Ag-1/ GM-Tg-cang-SE1533-Ag-2 Canine C9orf72 protein Canine
GM-Tg-bovg-SE1533-Ag-1/ GM-Tg-bovg-SE1533-Ag-2 Bovine C9orf72 protein Bovine
GM-Tg-equg-SE1533-Ag-1/ GM-Tg-equg-SE1533-Ag-2 Equine C9orf72 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1533-Ag-1/ GM-Tg-hg-SE1533-Ag-2; GM-Tg-rg-SE1533-Ag-1/ GM-Tg-rg-SE1533-Ag-2;
GM-Tg-mg-SE1533-Ag-1/ GM-Tg-mg-SE1533-Ag-2; GM-Tg-cynog-SE1533-Ag-1/ GM-Tg-cynog-SE1533-Ag-2;
GM-Tg-felg-SE1533-Ag-1/ GM-Tg-felg-SE1533-Ag-2; GM-Tg-cang-SE1533-Ag-1/ GM-Tg-cang-SE1533-Ag-2;
GM-Tg-bovg-SE1533-Ag-1/ GM-Tg-bovg-SE1533-Ag-2; GM-Tg-equg-SE1533-Ag-1/ GM-Tg-equg-SE1533-Ag-2
Products Name C9orf72 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name C9orf72
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine C9orf72 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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