Recombinant multi-species FHOD3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FHOD3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the diaphanous-related formins (DRF), and contains multiple domains, including GBD (GTPase-binding domain), DID (diaphanous inhibitory domain), FH1 (formin homology 1), FH2 (formin homology 2), and DAD (diaphanous auto-regulatory domain) domains. This protein is thought to play a role in actin filament polymerization in cardiomyocytes. Mutations in this gene have been associated with dilated cardiomyopathy (DCM), characterized by dilation of the ventricular chamber, leading to impairment of systolic pump function and subsequent heart failure. Increased levels of the protein encoded by this gene have been observed in individuals with hypertrophic cardiomyopathy (HCM). Alternative splicing results in multiple transcript variants encoding different isoforms. A muscle-specific isoform has been shown to possess a casein kinase 2 (CK2) phosphorylation site at the C-terminal end of the FH2 domain. Phosphorylation of this site alters its interaction with sequestosome 1 (SQSTM1), and targets this isoform to myofibrils, while other isoforms form cytoplasmic aggregates. [provided by RefSeq, Aug 2015]
The Alternative Names of target: FHOD3,FH1/FH2 domain-containing protein 3,Formactin-2, Formin homolog overexpressed in spleen 2 (hFHOS2),CMH28,FHOS2,Formactin2

Target products collectionGo to FHOD3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1501-Ab-1/ GM-Tg-hg-SE1501-Ab-2 Human FHOD3 protein Human
GM-Tg-rg-SE1501-Ab-1/ GM-Tg-rg-SE1501-Ab-2 Rat FHOD3 protein Rat
GM-Tg-mg-SE1501-Ab-1/ GM-Tg-mg-SE1501-Ab-2 Mouse FHOD3 protein Mouse
GM-Tg-cynog-SE1501-Ab-1/ GM-Tg-cynog-SE1501-Ab-2 Cynomolgus/Rhesus macaque FHOD3 monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1501-Ab-1/ GM-Tg-felg-SE1501-Ab-2 Feline FHOD3 protein Feline
GM-Tg-cang-SE1501-Ab-1/ GM-Tg-cang-SE1501-Ab-2 Canine FHOD3 protein Canine
GM-Tg-bovg-SE1501-Ab-1/ GM-Tg-bovg-SE1501-Ab-2 Bovine FHOD3 protein Bovine
GM-Tg-equg-SE1501-Ab-1/ GM-Tg-equg-SE1501-Ab-2 Equine FHOD3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1501-Ab-1/ GM-Tg-hg-SE1501-Ab-2; GM-Tg-rg-SE1501-Ab-1/ GM-Tg-rg-SE1501-Ab-2;
GM-Tg-mg-SE1501-Ab-1/ GM-Tg-mg-SE1501-Ab-2; GM-Tg-cynog-SE1501-Ab-1/ GM-Tg-cynog-SE1501-Ab-2;
GM-Tg-felg-SE1501-Ab-1/ GM-Tg-felg-SE1501-Ab-2; GM-Tg-cang-SE1501-Ab-1/ GM-Tg-cang-SE1501-Ab-2;
GM-Tg-bovg-SE1501-Ab-1/ GM-Tg-bovg-SE1501-Ab-2; GM-Tg-equg-SE1501-Ab-1/ GM-Tg-equg-SE1501-Ab-2
Products Name FHOD3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name FHOD3
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FHOD3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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