Recombinant multi-species PDH E1 Alpha/PDHA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDH E1 Alpha/PDHA1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]
The Alternative Names of target: E1alpha,PDH E1 Alpha,PDHA,PDHA1,PDHAD,PDHCE1A,PDHE1-A type I,PHE1A,Pdha-1,Pdha1,Pyruvate dehydrogenase E1 component subunit alpha,mitochondrial,somatic form

Target products collectionGo to PDH E1 Alpha/PDHA1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1495-Ag-1/ GM-Tg-hg-SE1495-Ag-2 Human PDH E1 Alpha/PDHA1 protein Human
GM-Tg-rg-SE1495-Ag-1/ GM-Tg-rg-SE1495-Ag-2 Rat PDH E1 Alpha/PDHA1 protein Rat
GM-Tg-mg-SE1495-Ag-1/ GM-Tg-mg-SE1495-Ag-2 Mouse PDH E1 Alpha/PDHA1 protein Mouse
GM-Tg-cynog-SE1495-Ag-1/ GM-Tg-cynog-SE1495-Ag-2 Cynomolgus/Rhesus macaque PDH E1 Alpha/PDHA1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1495-Ag-1/ GM-Tg-felg-SE1495-Ag-2 Feline PDH E1 Alpha/PDHA1 protein Feline
GM-Tg-cang-SE1495-Ag-1/ GM-Tg-cang-SE1495-Ag-2 Canine PDH E1 Alpha/PDHA1 protein Canine
GM-Tg-bovg-SE1495-Ag-1/ GM-Tg-bovg-SE1495-Ag-2 Bovine PDH E1 Alpha/PDHA1 protein Bovine
GM-Tg-equg-SE1495-Ag-1/ GM-Tg-equg-SE1495-Ag-2 Equine PDH E1 Alpha/PDHA1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1495-Ag-1/ GM-Tg-hg-SE1495-Ag-2; GM-Tg-rg-SE1495-Ag-1/ GM-Tg-rg-SE1495-Ag-2;
GM-Tg-mg-SE1495-Ag-1/ GM-Tg-mg-SE1495-Ag-2; GM-Tg-cynog-SE1495-Ag-1/ GM-Tg-cynog-SE1495-Ag-2;
GM-Tg-felg-SE1495-Ag-1/ GM-Tg-felg-SE1495-Ag-2; GM-Tg-cang-SE1495-Ag-1/ GM-Tg-cang-SE1495-Ag-2;
GM-Tg-bovg-SE1495-Ag-1/ GM-Tg-bovg-SE1495-Ag-2; GM-Tg-equg-SE1495-Ag-1/ GM-Tg-equg-SE1495-Ag-2
Products Name PDH E1 Alpha/PDHA1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PDH E1 Alpha/PDHA1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDH E1 Alpha/PDHA1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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