Recombinant multi-species LGI1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LGI1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the secreted leucine-rich repeat (LRR) superfamily and shares homology with members of the SLIT protein family. The encoded protein may regulate the activity of voltage-gated potassium channels and may be involved in neuronal growth regulation and cell survival. This gene is rearranged as a result of translocations in glioblastoma cell lines, and it is frequently down-regulated or rearranged in malignant gliomas. Mutations in this gene result in autosomal dominant lateral temporal epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
The Alternative Names of target: ADLTE,ADPAEF,ADPEAF,EPITEMPIN,EPT,ETL1,Epitempin-1,IB1099,LGI1,Leucine-rich glioma-inactivated protein 1,Lgi1

Target products collectionGo to LGI1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE1069-Ag-1/ GM-Tg-hg-SE1069-Ag-2 Human LGI1 protein Human
GM-Tg-rg-SE1069-Ag-1/ GM-Tg-rg-SE1069-Ag-2 Rat LGI1 protein Rat
GM-Tg-mg-SE1069-Ag-1/ GM-Tg-mg-SE1069-Ag-2 Mouse LGI1 protein Mouse
GM-Tg-cynog-SE1069-Ag-1/ GM-Tg-cynog-SE1069-Ag-2 Cynomolgus/Rhesus macaque LGI1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE1069-Ag-1/ GM-Tg-felg-SE1069-Ag-2 Feline LGI1 protein Feline
GM-Tg-cang-SE1069-Ag-1/ GM-Tg-cang-SE1069-Ag-2 Canine LGI1 protein Canine
GM-Tg-bovg-SE1069-Ag-1/ GM-Tg-bovg-SE1069-Ag-2 Bovine LGI1 protein Bovine
GM-Tg-equg-SE1069-Ag-1/ GM-Tg-equg-SE1069-Ag-2 Equine LGI1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE1069-Ag-1/ GM-Tg-hg-SE1069-Ag-2; GM-Tg-rg-SE1069-Ag-1/ GM-Tg-rg-SE1069-Ag-2;
GM-Tg-mg-SE1069-Ag-1/ GM-Tg-mg-SE1069-Ag-2; GM-Tg-cynog-SE1069-Ag-1/ GM-Tg-cynog-SE1069-Ag-2;
GM-Tg-felg-SE1069-Ag-1/ GM-Tg-felg-SE1069-Ag-2; GM-Tg-cang-SE1069-Ag-1/ GM-Tg-cang-SE1069-Ag-2;
GM-Tg-bovg-SE1069-Ag-1/ GM-Tg-bovg-SE1069-Ag-2; GM-Tg-equg-SE1069-Ag-1/ GM-Tg-equg-SE1069-Ag-2
Products Name LGI1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LGI1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LGI1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.