Recombinant multi-species COL4A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine COL4A1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
The Alternative Names of target: BSVD,BSVD1,Bru,COL4A1,COL4A1s,Col4a-1,Col4a1,Collagen alpha-1(IV) chain,PADMAL,RATOR,Raw,Svc

Target products collectionGo to COL4A1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0799-Ag-1/ GM-Tg-hg-SE0799-Ag-2 Human COL4A1 protein Human
GM-Tg-rg-SE0799-Ag-1/ GM-Tg-rg-SE0799-Ag-2 Rat COL4A1 protein Rat
GM-Tg-mg-SE0799-Ag-1/ GM-Tg-mg-SE0799-Ag-2 Mouse COL4A1 protein Mouse
GM-Tg-cynog-SE0799-Ag-1/ GM-Tg-cynog-SE0799-Ag-2 Cynomolgus/Rhesus macaque COL4A1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0799-Ag-1/ GM-Tg-felg-SE0799-Ag-2 Feline COL4A1 protein Feline
GM-Tg-cang-SE0799-Ag-1/ GM-Tg-cang-SE0799-Ag-2 Canine COL4A1 protein Canine
GM-Tg-bovg-SE0799-Ag-1/ GM-Tg-bovg-SE0799-Ag-2 Bovine COL4A1 protein Bovine
GM-Tg-equg-SE0799-Ag-1/ GM-Tg-equg-SE0799-Ag-2 Equine COL4A1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0799-Ag-1/ GM-Tg-hg-SE0799-Ag-2; GM-Tg-rg-SE0799-Ag-1/ GM-Tg-rg-SE0799-Ag-2;
GM-Tg-mg-SE0799-Ag-1/ GM-Tg-mg-SE0799-Ag-2; GM-Tg-cynog-SE0799-Ag-1/ GM-Tg-cynog-SE0799-Ag-2;
GM-Tg-felg-SE0799-Ag-1/ GM-Tg-felg-SE0799-Ag-2; GM-Tg-cang-SE0799-Ag-1/ GM-Tg-cang-SE0799-Ag-2;
GM-Tg-bovg-SE0799-Ag-1/ GM-Tg-bovg-SE0799-Ag-2; GM-Tg-equg-SE0799-Ag-1/ GM-Tg-equg-SE0799-Ag-2
Products Name COL4A1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name COL4A1
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine COL4A1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.