Recombinant multi-species C2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine C2 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Component C2 is a serum glycoprotein that functions as part of the classical pathway of the complement system. Activated C1 cleaves C2 into C2a and C2b. The serine proteinase C2a then combines with complement factor 4b to create the C3 or C5 convertase. Deficiency of C2 has been reported to associated with certain autoimmune diseases and SNPs in this gene have been associated with altered susceptibility to age-related macular degeneration. This gene localizes within the class III region of the MHC on the short arm of chromosome 6. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described in publications but their full-length sequence has not been determined.[provided by RefSeq, Mar 2009]
The Alternative Names of target: ARMD14,C2,C3/C5 convertase,CO2,Complement C2

Target products collectionGo to C2 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0720-Ag-1/ GM-Tg-hg-SE0720-Ag-2 Human C2 protein Human
GM-Tg-rg-SE0720-Ag-1/ GM-Tg-rg-SE0720-Ag-2 Rat C2 protein Rat
GM-Tg-mg-SE0720-Ag-1/ GM-Tg-mg-SE0720-Ag-2 Mouse C2 protein Mouse
GM-Tg-cynog-SE0720-Ag-1/ GM-Tg-cynog-SE0720-Ag-2 Cynomolgus/Rhesus macaque C2 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0720-Ag-1/ GM-Tg-felg-SE0720-Ag-2 Feline C2 protein Feline
GM-Tg-cang-SE0720-Ag-1/ GM-Tg-cang-SE0720-Ag-2 Canine C2 protein Canine
GM-Tg-bovg-SE0720-Ag-1/ GM-Tg-bovg-SE0720-Ag-2 Bovine C2 protein Bovine
GM-Tg-equg-SE0720-Ag-1/ GM-Tg-equg-SE0720-Ag-2 Equine C2 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0720-Ag-1/ GM-Tg-hg-SE0720-Ag-2; GM-Tg-rg-SE0720-Ag-1/ GM-Tg-rg-SE0720-Ag-2;
GM-Tg-mg-SE0720-Ag-1/ GM-Tg-mg-SE0720-Ag-2; GM-Tg-cynog-SE0720-Ag-1/ GM-Tg-cynog-SE0720-Ag-2;
GM-Tg-felg-SE0720-Ag-1/ GM-Tg-felg-SE0720-Ag-2; GM-Tg-cang-SE0720-Ag-1/ GM-Tg-cang-SE0720-Ag-2;
GM-Tg-bovg-SE0720-Ag-1/ GM-Tg-bovg-SE0720-Ag-2; GM-Tg-equg-SE0720-Ag-1/ GM-Tg-equg-SE0720-Ag-2
Products Name C2 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name C2
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine C2 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.