Recombinant multi-species Selenoprotein P/SELENOP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Selenoprotein P/SELENOP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (10 in human), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. The use of alternative polyadenylation sites, one located in between the two SECIS elements, results in two populations of mRNAs containing either both (predominant) or just the upstream SECIS element (PMID:27881738). Alternatively spliced transcript variants have also been found for this gene. [provided by RefSeq, Oct 2018]
The Alternative Names of target: D15Ucla1,SELENOP,SELP,SEPP,SEPP1,Se-P,SeP,Selenop,Selenoprotein P,Sepp1,selp

Target products collectionGo to Selenoprotein P/SELENOP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0464-Ag-1/ GM-Tg-hg-SE0464-Ag-2 Human Selenoprotein P/SELENOP protein Human
GM-Tg-rg-SE0464-Ag-1/ GM-Tg-rg-SE0464-Ag-2 Rat Selenoprotein P/SELENOP protein Rat
GM-Tg-mg-SE0464-Ag-1/ GM-Tg-mg-SE0464-Ag-2 Mouse Selenoprotein P/SELENOP protein Mouse
GM-Tg-cynog-SE0464-Ag-1/ GM-Tg-cynog-SE0464-Ag-2 Cynomolgus/Rhesus macaque Selenoprotein P/SELENOP protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0464-Ag-1/ GM-Tg-felg-SE0464-Ag-2 Feline Selenoprotein P/SELENOP protein Feline
GM-Tg-cang-SE0464-Ag-1/ GM-Tg-cang-SE0464-Ag-2 Canine Selenoprotein P/SELENOP protein Canine
GM-Tg-bovg-SE0464-Ag-1/ GM-Tg-bovg-SE0464-Ag-2 Bovine Selenoprotein P/SELENOP protein Bovine
GM-Tg-equg-SE0464-Ag-1/ GM-Tg-equg-SE0464-Ag-2 Equine Selenoprotein P/SELENOP protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0464-Ag-1/ GM-Tg-hg-SE0464-Ag-2; GM-Tg-rg-SE0464-Ag-1/ GM-Tg-rg-SE0464-Ag-2;
GM-Tg-mg-SE0464-Ag-1/ GM-Tg-mg-SE0464-Ag-2; GM-Tg-cynog-SE0464-Ag-1/ GM-Tg-cynog-SE0464-Ag-2;
GM-Tg-felg-SE0464-Ag-1/ GM-Tg-felg-SE0464-Ag-2; GM-Tg-cang-SE0464-Ag-1/ GM-Tg-cang-SE0464-Ag-2;
GM-Tg-bovg-SE0464-Ag-1/ GM-Tg-bovg-SE0464-Ag-2; GM-Tg-equg-SE0464-Ag-1/ GM-Tg-equg-SE0464-Ag-2
Products Name Selenoprotein P/SELENOP protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Selenoprotein P/SELENOP
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Selenoprotein P/SELENOP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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