Recombinant multi-species NRG3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NRG3 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]
The Alternative Names of target: HRG3,NRG3,Nrg3,Pro-NRG3,Pro-neuregulin-3,RGD1559678,membrane-bound isoform,pro-NRG3,ska

Target products collectionGo to NRG3 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0375-Ag-1/ GM-Tg-hg-SE0375-Ag-2 Human NRG3 protein Human
GM-Tg-rg-SE0375-Ag-1/ GM-Tg-rg-SE0375-Ag-2 Rat NRG3 protein Rat
GM-Tg-mg-SE0375-Ag-1/ GM-Tg-mg-SE0375-Ag-2 Mouse NRG3 protein Mouse
GM-Tg-cynog-SE0375-Ag-1/ GM-Tg-cynog-SE0375-Ag-2 Cynomolgus/Rhesus macaque NRG3 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0375-Ag-1/ GM-Tg-felg-SE0375-Ag-2 Feline NRG3 protein Feline
GM-Tg-cang-SE0375-Ag-1/ GM-Tg-cang-SE0375-Ag-2 Canine NRG3 protein Canine
GM-Tg-bovg-SE0375-Ag-1/ GM-Tg-bovg-SE0375-Ag-2 Bovine NRG3 protein Bovine
GM-Tg-equg-SE0375-Ag-1/ GM-Tg-equg-SE0375-Ag-2 Equine NRG3 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0375-Ag-1/ GM-Tg-hg-SE0375-Ag-2; GM-Tg-rg-SE0375-Ag-1/ GM-Tg-rg-SE0375-Ag-2;
GM-Tg-mg-SE0375-Ag-1/ GM-Tg-mg-SE0375-Ag-2; GM-Tg-cynog-SE0375-Ag-1/ GM-Tg-cynog-SE0375-Ag-2;
GM-Tg-felg-SE0375-Ag-1/ GM-Tg-felg-SE0375-Ag-2; GM-Tg-cang-SE0375-Ag-1/ GM-Tg-cang-SE0375-Ag-2;
GM-Tg-bovg-SE0375-Ag-1/ GM-Tg-bovg-SE0375-Ag-2; GM-Tg-equg-SE0375-Ag-1/ GM-Tg-equg-SE0375-Ag-2
Products Name NRG3 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NRG3
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NRG3 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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