Recombinant multi-species LAMA4/Laminin alpha 4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LAMA4/Laminin alpha 4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the alpha chain isoform laminin, alpha 4. The domain structure of alpha 4 is similar to that of alpha 3, both of which resemble truncated versions of alpha 1 and alpha 2, in that approximately 1,200 residues at the N-terminus (domains IV, V and VI) have been lost. Laminin, alpha 4 contains the C-terminal G domain which distinguishes all alpha chains from the beta and gamma chains. The RNA analysis from adult and fetal tissues revealed developmental regulation of expression, however, the exact function of laminin, alpha 4 is not known. Tissue-specific utilization of alternative polyA-signal has been described in literature. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
The Alternative Names of target: CMD1JJ,LAMA3,LAMA4,LAMA4*-1,Lama4,Laminin alpha 4,Laminin subunit alpha-4,Laminin-14 subunit alpha,Laminin-8 subunit alpha,Laminin-9 subunit alpha,RGD1560062

Target products collectionGo to LAMA4/Laminin alpha 4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0298-Ag-1/ GM-Tg-hg-SE0298-Ag-2 Human LAMA4/Laminin alpha 4 protein Human
GM-Tg-rg-SE0298-Ag-1/ GM-Tg-rg-SE0298-Ag-2 Rat LAMA4/Laminin alpha 4 protein Rat
GM-Tg-mg-SE0298-Ag-1/ GM-Tg-mg-SE0298-Ag-2 Mouse LAMA4/Laminin alpha 4 protein Mouse
GM-Tg-cynog-SE0298-Ag-1/ GM-Tg-cynog-SE0298-Ag-2 Cynomolgus/Rhesus macaque LAMA4/Laminin alpha 4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0298-Ag-1/ GM-Tg-felg-SE0298-Ag-2 Feline LAMA4/Laminin alpha 4 protein Feline
GM-Tg-cang-SE0298-Ag-1/ GM-Tg-cang-SE0298-Ag-2 Canine LAMA4/Laminin alpha 4 protein Canine
GM-Tg-bovg-SE0298-Ag-1/ GM-Tg-bovg-SE0298-Ag-2 Bovine LAMA4/Laminin alpha 4 protein Bovine
GM-Tg-equg-SE0298-Ag-1/ GM-Tg-equg-SE0298-Ag-2 Equine LAMA4/Laminin alpha 4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0298-Ag-1/ GM-Tg-hg-SE0298-Ag-2; GM-Tg-rg-SE0298-Ag-1/ GM-Tg-rg-SE0298-Ag-2;
GM-Tg-mg-SE0298-Ag-1/ GM-Tg-mg-SE0298-Ag-2; GM-Tg-cynog-SE0298-Ag-1/ GM-Tg-cynog-SE0298-Ag-2;
GM-Tg-felg-SE0298-Ag-1/ GM-Tg-felg-SE0298-Ag-2; GM-Tg-cang-SE0298-Ag-1/ GM-Tg-cang-SE0298-Ag-2;
GM-Tg-bovg-SE0298-Ag-1/ GM-Tg-bovg-SE0298-Ag-2; GM-Tg-equg-SE0298-Ag-1/ GM-Tg-equg-SE0298-Ag-2
Products Name LAMA4/Laminin alpha 4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name LAMA4/Laminin alpha 4
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine LAMA4/Laminin alpha 4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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