Recombinant multi-species DSE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DSE protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a tumor-rejection antigen. It is localized to the endoplasmic reticulum and functions to convert D-glucuronic acid to L-iduronic acid during the biosynthesis of dermatan sulfate. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. Mutations in this gene cause inmusculocontractural Ehlers-Danlos syndrome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 9, and a paralogous gene exists on chromosome 18. [provided by RefSeq, Apr 2016]
The Alternative Names of target: DSE,Dermatan-sulfate epimerase,DS epimerase,Chondroitin-glucuronate 5-epimerase, Squamous cell carcinoma antigen recognized by T-cells 2 (SART-2),DSEP,DSEPI,SART2,EDSMC2,SART-2,DS-epi1

Target products collectionGo to DSE products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-SE0163-Ab-1/ GM-Tg-hg-SE0163-Ab-2 Human DSE protein Human
GM-Tg-rg-SE0163-Ab-1/ GM-Tg-rg-SE0163-Ab-2 Rat DSE protein Rat
GM-Tg-mg-SE0163-Ab-1/ GM-Tg-mg-SE0163-Ab-2 Mouse DSE protein Mouse
GM-Tg-cynog-SE0163-Ab-1/ GM-Tg-cynog-SE0163-Ab-2 Cynomolgus/Rhesus macaque DSE monoclonal antibody Cynomolgus/ Rhesus macaque
GM-Tg-felg-SE0163-Ab-1/ GM-Tg-felg-SE0163-Ab-2 Feline DSE protein Feline
GM-Tg-cang-SE0163-Ab-1/ GM-Tg-cang-SE0163-Ab-2 Canine DSE protein Canine
GM-Tg-bovg-SE0163-Ab-1/ GM-Tg-bovg-SE0163-Ab-2 Bovine DSE protein Bovine
GM-Tg-equg-SE0163-Ab-1/ GM-Tg-equg-SE0163-Ab-2 Equine DSE protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-SE0163-Ab-1/ GM-Tg-hg-SE0163-Ab-2; GM-Tg-rg-SE0163-Ab-1/ GM-Tg-rg-SE0163-Ab-2;
GM-Tg-mg-SE0163-Ab-1/ GM-Tg-mg-SE0163-Ab-2; GM-Tg-cynog-SE0163-Ab-1/ GM-Tg-cynog-SE0163-Ab-2;
GM-Tg-felg-SE0163-Ab-1/ GM-Tg-felg-SE0163-Ab-2; GM-Tg-cang-SE0163-Ab-1/ GM-Tg-cang-SE0163-Ab-2;
GM-Tg-bovg-SE0163-Ab-1/ GM-Tg-bovg-SE0163-Ab-2; GM-Tg-equg-SE0163-Ab-1/ GM-Tg-equg-SE0163-Ab-2
Products Name DSE protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DSE
Protein Sub-location Secreted Protein/Potential Cytokines
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DSE protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.