Recombinant multi-species PDP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDP1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]
The Alternative Names of target: Gm1024,PDH,PDP,PDP 1,PDP1,PDPC,PDPC 1,PDPc,PPM2A,PPM2C,Pdp1,Ppm2c,Protein phosphatase 2C,Pyruvate dehydrogenase phosphatase catalytic subunit 1 (PDPC 1),[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1,mitochondrial

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(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9789-Ag-1/ GM-Tg-hg-IP9789-Ag-2 Human PDP1 protein Human
GM-Tg-rg-IP9789-Ag-1/ GM-Tg-rg-IP9789-Ag-2 Rat PDP1 protein Rat
GM-Tg-mg-IP9789-Ag-1/ GM-Tg-mg-IP9789-Ag-2 Mouse PDP1 protein Mouse
GM-Tg-cynog-IP9789-Ag-1/ GM-Tg-cynog-IP9789-Ag-2 Cynomolgus/Rhesus macaque PDP1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9789-Ag-1/ GM-Tg-felg-IP9789-Ag-2 Feline PDP1 protein Feline
GM-Tg-cang-IP9789-Ag-1/ GM-Tg-cang-IP9789-Ag-2 Canine PDP1 protein Canine
GM-Tg-bovg-IP9789-Ag-1/ GM-Tg-bovg-IP9789-Ag-2 Bovine PDP1 protein Bovine
GM-Tg-equg-IP9789-Ag-1/ GM-Tg-equg-IP9789-Ag-2 Equine PDP1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9789-Ag-1/ GM-Tg-hg-IP9789-Ag-2; GM-Tg-rg-IP9789-Ag-1/ GM-Tg-rg-IP9789-Ag-2;
GM-Tg-mg-IP9789-Ag-1/ GM-Tg-mg-IP9789-Ag-2; GM-Tg-cynog-IP9789-Ag-1/ GM-Tg-cynog-IP9789-Ag-2;
GM-Tg-felg-IP9789-Ag-1/ GM-Tg-felg-IP9789-Ag-2; GM-Tg-cang-IP9789-Ag-1/ GM-Tg-cang-IP9789-Ag-2;
GM-Tg-bovg-IP9789-Ag-1/ GM-Tg-bovg-IP9789-Ag-2; GM-Tg-equg-IP9789-Ag-1/ GM-Tg-equg-IP9789-Ag-2
Products Name PDP1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name PDP1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine PDP1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.