Recombinant multi-species RPB5/POLR2E protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RPB5/POLR2E protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit is shared by the other two DNA-directed RNA polymerases and is present in two-fold molar excess over the other polymerase subunits. An interaction between this subunit and a hepatitis virus transactivating protein has been demonstrated, suggesting that interaction between transcriptional activators and the polymerase can occur through this subunit. A pseudogene is located on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
The Alternative Names of target: 2410021N14Rik,25kDa,DNA-directed RNA polymerase II 23 kDa polypeptide,DNA-directed RNA polymerase II subunit E,DNA-directed RNA polymerases I,II,POLR2E,Polr2e,RNA polymerases I,RPABC1,RPB5,RPB5 homolog,XAP4,and III subunit ABC1,and III subunit RPABC1,hRPB25,hsRPB5

Target products collectionGo to RPB5/POLR2E products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9689-Ag-1/ GM-Tg-hg-IP9689-Ag-2 Human RPB5/POLR2E protein Human
GM-Tg-rg-IP9689-Ag-1/ GM-Tg-rg-IP9689-Ag-2 Rat RPB5/POLR2E protein Rat
GM-Tg-mg-IP9689-Ag-1/ GM-Tg-mg-IP9689-Ag-2 Mouse RPB5/POLR2E protein Mouse
GM-Tg-cynog-IP9689-Ag-1/ GM-Tg-cynog-IP9689-Ag-2 Cynomolgus/Rhesus macaque RPB5/POLR2E protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9689-Ag-1/ GM-Tg-felg-IP9689-Ag-2 Feline RPB5/POLR2E protein Feline
GM-Tg-cang-IP9689-Ag-1/ GM-Tg-cang-IP9689-Ag-2 Canine RPB5/POLR2E protein Canine
GM-Tg-bovg-IP9689-Ag-1/ GM-Tg-bovg-IP9689-Ag-2 Bovine RPB5/POLR2E protein Bovine
GM-Tg-equg-IP9689-Ag-1/ GM-Tg-equg-IP9689-Ag-2 Equine RPB5/POLR2E protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9689-Ag-1/ GM-Tg-hg-IP9689-Ag-2; GM-Tg-rg-IP9689-Ag-1/ GM-Tg-rg-IP9689-Ag-2;
GM-Tg-mg-IP9689-Ag-1/ GM-Tg-mg-IP9689-Ag-2; GM-Tg-cynog-IP9689-Ag-1/ GM-Tg-cynog-IP9689-Ag-2;
GM-Tg-felg-IP9689-Ag-1/ GM-Tg-felg-IP9689-Ag-2; GM-Tg-cang-IP9689-Ag-1/ GM-Tg-cang-IP9689-Ag-2;
GM-Tg-bovg-IP9689-Ag-1/ GM-Tg-bovg-IP9689-Ag-2; GM-Tg-equg-IP9689-Ag-1/ GM-Tg-equg-IP9689-Ag-2
Products Name RPB5/POLR2E protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name RPB5/POLR2E
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine RPB5/POLR2E protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.