Recombinant multi-species POLH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine POLH protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
The Alternative Names of target: DNA polymerase eta,POLH,Polh,RAD30,RAD30 homolog A,RAD30A,XP-V,XPV,Xeroderma pigmentosum variant type protein

Target products collectionGo to POLH products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9687-Ag-1/ GM-Tg-hg-IP9687-Ag-2 Human POLH protein Human
GM-Tg-rg-IP9687-Ag-1/ GM-Tg-rg-IP9687-Ag-2 Rat POLH protein Rat
GM-Tg-mg-IP9687-Ag-1/ GM-Tg-mg-IP9687-Ag-2 Mouse POLH protein Mouse
GM-Tg-cynog-IP9687-Ag-1/ GM-Tg-cynog-IP9687-Ag-2 Cynomolgus/Rhesus macaque POLH protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9687-Ag-1/ GM-Tg-felg-IP9687-Ag-2 Feline POLH protein Feline
GM-Tg-cang-IP9687-Ag-1/ GM-Tg-cang-IP9687-Ag-2 Canine POLH protein Canine
GM-Tg-bovg-IP9687-Ag-1/ GM-Tg-bovg-IP9687-Ag-2 Bovine POLH protein Bovine
GM-Tg-equg-IP9687-Ag-1/ GM-Tg-equg-IP9687-Ag-2 Equine POLH protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9687-Ag-1/ GM-Tg-hg-IP9687-Ag-2; GM-Tg-rg-IP9687-Ag-1/ GM-Tg-rg-IP9687-Ag-2;
GM-Tg-mg-IP9687-Ag-1/ GM-Tg-mg-IP9687-Ag-2; GM-Tg-cynog-IP9687-Ag-1/ GM-Tg-cynog-IP9687-Ag-2;
GM-Tg-felg-IP9687-Ag-1/ GM-Tg-felg-IP9687-Ag-2; GM-Tg-cang-IP9687-Ag-1/ GM-Tg-cang-IP9687-Ag-2;
GM-Tg-bovg-IP9687-Ag-1/ GM-Tg-bovg-IP9687-Ag-2; GM-Tg-equg-IP9687-Ag-1/ GM-Tg-equg-IP9687-Ag-2
Products Name POLH protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name POLH
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine POLH protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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