Recombinant multi-species Antizyme inhibitor 1/AZIN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Antizyme inhibitor 1/AZIN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 1, the first member of this gene family that is ubiquitously expressed, and is localized in the nucleus and cytoplasm. Overexpression of antizyme inhibitor 1 gene has been associated with increased proliferation, cellular transformation and tumorigenesis. Gene knockout studies showed that homozygous mutant mice lacking functional antizyme inhibitor 1 gene died at birth with abnormal liver morphology. RNA editing of this gene, predominantly in the liver tissue, has been linked to the progression of hepatocellular carcinoma. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2014]
The Alternative Names of target: 1700085L02Rik,AZI,AZI1,AZIA1,AZIN1,Antizyme inhibitor 1,Azin1,OAZI,OAZIN,ODC1L,Oazi,Oazin,Ornithine decarboxylase antizyme inhibitor

Target products collectionGo to Antizyme inhibitor 1/AZIN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9485-Ag-1/ GM-Tg-hg-IP9485-Ag-2 Human Antizyme inhibitor 1/AZIN1 protein Human
GM-Tg-rg-IP9485-Ag-1/ GM-Tg-rg-IP9485-Ag-2 Rat Antizyme inhibitor 1/AZIN1 protein Rat
GM-Tg-mg-IP9485-Ag-1/ GM-Tg-mg-IP9485-Ag-2 Mouse Antizyme inhibitor 1/AZIN1 protein Mouse
GM-Tg-cynog-IP9485-Ag-1/ GM-Tg-cynog-IP9485-Ag-2 Cynomolgus/Rhesus macaque Antizyme inhibitor 1/AZIN1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9485-Ag-1/ GM-Tg-felg-IP9485-Ag-2 Feline Antizyme inhibitor 1/AZIN1 protein Feline
GM-Tg-cang-IP9485-Ag-1/ GM-Tg-cang-IP9485-Ag-2 Canine Antizyme inhibitor 1/AZIN1 protein Canine
GM-Tg-bovg-IP9485-Ag-1/ GM-Tg-bovg-IP9485-Ag-2 Bovine Antizyme inhibitor 1/AZIN1 protein Bovine
GM-Tg-equg-IP9485-Ag-1/ GM-Tg-equg-IP9485-Ag-2 Equine Antizyme inhibitor 1/AZIN1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9485-Ag-1/ GM-Tg-hg-IP9485-Ag-2; GM-Tg-rg-IP9485-Ag-1/ GM-Tg-rg-IP9485-Ag-2;
GM-Tg-mg-IP9485-Ag-1/ GM-Tg-mg-IP9485-Ag-2; GM-Tg-cynog-IP9485-Ag-1/ GM-Tg-cynog-IP9485-Ag-2;
GM-Tg-felg-IP9485-Ag-1/ GM-Tg-felg-IP9485-Ag-2; GM-Tg-cang-IP9485-Ag-1/ GM-Tg-cang-IP9485-Ag-2;
GM-Tg-bovg-IP9485-Ag-1/ GM-Tg-bovg-IP9485-Ag-2; GM-Tg-equg-IP9485-Ag-1/ GM-Tg-equg-IP9485-Ag-2
Products Name Antizyme inhibitor 1/AZIN1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Antizyme inhibitor 1/AZIN1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Antizyme inhibitor 1/AZIN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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