Recombinant multi-species OAZ1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine OAZ1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
The Alternative Names of target: AZ-1,AZ1,AZI,Antizyme,OAZ,OAZ1,ODC-Az,ODCAC,Oaz,Oaz1,Ornithine decarboxylase antizyme 1

Target products collectionGo to OAZ1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9156-Ag-1/ GM-Tg-hg-IP9156-Ag-2 Human OAZ1 protein Human
GM-Tg-rg-IP9156-Ag-1/ GM-Tg-rg-IP9156-Ag-2 Rat OAZ1 protein Rat
GM-Tg-mg-IP9156-Ag-1/ GM-Tg-mg-IP9156-Ag-2 Mouse OAZ1 protein Mouse
GM-Tg-cynog-IP9156-Ag-1/ GM-Tg-cynog-IP9156-Ag-2 Cynomolgus/Rhesus macaque OAZ1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9156-Ag-1/ GM-Tg-felg-IP9156-Ag-2 Feline OAZ1 protein Feline
GM-Tg-cang-IP9156-Ag-1/ GM-Tg-cang-IP9156-Ag-2 Canine OAZ1 protein Canine
GM-Tg-bovg-IP9156-Ag-1/ GM-Tg-bovg-IP9156-Ag-2 Bovine OAZ1 protein Bovine
GM-Tg-equg-IP9156-Ag-1/ GM-Tg-equg-IP9156-Ag-2 Equine OAZ1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9156-Ag-1/ GM-Tg-hg-IP9156-Ag-2; GM-Tg-rg-IP9156-Ag-1/ GM-Tg-rg-IP9156-Ag-2;
GM-Tg-mg-IP9156-Ag-1/ GM-Tg-mg-IP9156-Ag-2; GM-Tg-cynog-IP9156-Ag-1/ GM-Tg-cynog-IP9156-Ag-2;
GM-Tg-felg-IP9156-Ag-1/ GM-Tg-felg-IP9156-Ag-2; GM-Tg-cang-IP9156-Ag-1/ GM-Tg-cang-IP9156-Ag-2;
GM-Tg-bovg-IP9156-Ag-1/ GM-Tg-bovg-IP9156-Ag-2; GM-Tg-equg-IP9156-Ag-1/ GM-Tg-equg-IP9156-Ag-2
Products Name OAZ1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name OAZ1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine OAZ1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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