Recombinant multi-species NUP98-NUP96/NUP98 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NUP98-NUP96/NUP98 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Nuclear pore complexes (NPCs) regulate the transport of macromolecules between the nucleus and cytoplasm, and are composed of many polypeptide subunits, many of which belong to the nucleoporin family. This gene belongs to the nucleoporin gene family and encodes a 186 kDa precursor protein that undergoes autoproteolytic cleavage to generate a 98 kDa nucleoporin and 96 kDa nucleoporin. The 98 kDa nucleoporin contains a Gly-Leu-Phe-Gly (GLGF) repeat domain and participates in many cellular processes, including nuclear import, nuclear export, mitotic progression, and regulation of gene expression. The 96 kDa nucleoporin is a scaffold component of the NPC. Proteolytic cleavage is important for targeting of the proteins to the NPC. Translocations between this gene and many other partner genes have been observed in different leukemias. Rearrangements typically result in chimeras with the N-terminal GLGF domain of this gene to the C-terminus of the partner gene. Alternative splicing results in multiple transcript variants encoding different isoforms, at least two of which are proteolytically processed. Some variants lack the region that encodes the 96 kDa nucleoporin. [provided by RefSeq, Feb 2016]
The Alternative Names of target: 4732457F17,ADIR2,NUP196,NUP96,NUP98,NUP98-96,NUP98-NUP96,Nuclear pore complex protein Nup98-Nup96,Nup96,Nup98,Nup98-96

Target products collectionGo to NUP98-NUP96/NUP98 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9139-Ag-1/ GM-Tg-hg-IP9139-Ag-2 Human NUP98-NUP96/NUP98 protein Human
GM-Tg-rg-IP9139-Ag-1/ GM-Tg-rg-IP9139-Ag-2 Rat NUP98-NUP96/NUP98 protein Rat
GM-Tg-mg-IP9139-Ag-1/ GM-Tg-mg-IP9139-Ag-2 Mouse NUP98-NUP96/NUP98 protein Mouse
GM-Tg-cynog-IP9139-Ag-1/ GM-Tg-cynog-IP9139-Ag-2 Cynomolgus/Rhesus macaque NUP98-NUP96/NUP98 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9139-Ag-1/ GM-Tg-felg-IP9139-Ag-2 Feline NUP98-NUP96/NUP98 protein Feline
GM-Tg-cang-IP9139-Ag-1/ GM-Tg-cang-IP9139-Ag-2 Canine NUP98-NUP96/NUP98 protein Canine
GM-Tg-bovg-IP9139-Ag-1/ GM-Tg-bovg-IP9139-Ag-2 Bovine NUP98-NUP96/NUP98 protein Bovine
GM-Tg-equg-IP9139-Ag-1/ GM-Tg-equg-IP9139-Ag-2 Equine NUP98-NUP96/NUP98 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9139-Ag-1/ GM-Tg-hg-IP9139-Ag-2; GM-Tg-rg-IP9139-Ag-1/ GM-Tg-rg-IP9139-Ag-2;
GM-Tg-mg-IP9139-Ag-1/ GM-Tg-mg-IP9139-Ag-2; GM-Tg-cynog-IP9139-Ag-1/ GM-Tg-cynog-IP9139-Ag-2;
GM-Tg-felg-IP9139-Ag-1/ GM-Tg-felg-IP9139-Ag-2; GM-Tg-cang-IP9139-Ag-1/ GM-Tg-cang-IP9139-Ag-2;
GM-Tg-bovg-IP9139-Ag-1/ GM-Tg-bovg-IP9139-Ag-2; GM-Tg-equg-IP9139-Ag-1/ GM-Tg-equg-IP9139-Ag-2
Products Name NUP98-NUP96/NUP98 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name NUP98-NUP96/NUP98
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine NUP98-NUP96/NUP98 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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