Recombinant multi-species Aconitase 1/ACO1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Aconitase 1/ACO1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants [provided by RefSeq, Jan 2014]
The Alternative Names of target: ACO1,ACONS,AH,Aco-1,Aco1,Acon1,Aconitase,Aconitase 1,Citrate hydro-lyase,Cytoplasmic aconitate hydratase,Ferritin repressor protein,HEL60,IREB1,IREBP,IREBP1,IRP1,Irebp,Iron regulatory protein 1 (IRP1),Iron-responsive element-binding protein 1 (IRE-BP 1),Irp1

Target products collectionGo to Aconitase 1/ACO1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP9105-Ag-1/ GM-Tg-hg-IP9105-Ag-2 Human Aconitase 1/ACO1 protein Human
GM-Tg-rg-IP9105-Ag-1/ GM-Tg-rg-IP9105-Ag-2 Rat Aconitase 1/ACO1 protein Rat
GM-Tg-mg-IP9105-Ag-1/ GM-Tg-mg-IP9105-Ag-2 Mouse Aconitase 1/ACO1 protein Mouse
GM-Tg-cynog-IP9105-Ag-1/ GM-Tg-cynog-IP9105-Ag-2 Cynomolgus/Rhesus macaque Aconitase 1/ACO1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP9105-Ag-1/ GM-Tg-felg-IP9105-Ag-2 Feline Aconitase 1/ACO1 protein Feline
GM-Tg-cang-IP9105-Ag-1/ GM-Tg-cang-IP9105-Ag-2 Canine Aconitase 1/ACO1 protein Canine
GM-Tg-bovg-IP9105-Ag-1/ GM-Tg-bovg-IP9105-Ag-2 Bovine Aconitase 1/ACO1 protein Bovine
GM-Tg-equg-IP9105-Ag-1/ GM-Tg-equg-IP9105-Ag-2 Equine Aconitase 1/ACO1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP9105-Ag-1/ GM-Tg-hg-IP9105-Ag-2; GM-Tg-rg-IP9105-Ag-1/ GM-Tg-rg-IP9105-Ag-2;
GM-Tg-mg-IP9105-Ag-1/ GM-Tg-mg-IP9105-Ag-2; GM-Tg-cynog-IP9105-Ag-1/ GM-Tg-cynog-IP9105-Ag-2;
GM-Tg-felg-IP9105-Ag-1/ GM-Tg-felg-IP9105-Ag-2; GM-Tg-cang-IP9105-Ag-1/ GM-Tg-cang-IP9105-Ag-2;
GM-Tg-bovg-IP9105-Ag-1/ GM-Tg-bovg-IP9105-Ag-2; GM-Tg-equg-IP9105-Ag-1/ GM-Tg-equg-IP9105-Ag-2
Products Name Aconitase 1/ACO1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name Aconitase 1/ACO1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine Aconitase 1/ACO1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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