Recombinant multi-species MTH1/NUDT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MTH1/NUDT1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A rare single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Dec 2018]
The Alternative Names of target: 2-hydroxy-dATP diphosphatase,7,8-dihydro-8-oxoguanine triphosphatase,8-oxo-dGTPase,MTH1,Methylated purine nucleoside triphosphate hydrolase,Mth1,NUDT1,Nucleoside diphosphate-linked moiety X motif 1 (Nudix motif 1),Nudt1,Oxidized purine nucleoside triphosphate hydrolase

Target products collectionGo to MTH1/NUDT1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8989-Ag-1/ GM-Tg-hg-IP8989-Ag-2 Human MTH1/NUDT1 protein Human
GM-Tg-rg-IP8989-Ag-1/ GM-Tg-rg-IP8989-Ag-2 Rat MTH1/NUDT1 protein Rat
GM-Tg-mg-IP8989-Ag-1/ GM-Tg-mg-IP8989-Ag-2 Mouse MTH1/NUDT1 protein Mouse
GM-Tg-cynog-IP8989-Ag-1/ GM-Tg-cynog-IP8989-Ag-2 Cynomolgus/Rhesus macaque MTH1/NUDT1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8989-Ag-1/ GM-Tg-felg-IP8989-Ag-2 Feline MTH1/NUDT1 protein Feline
GM-Tg-cang-IP8989-Ag-1/ GM-Tg-cang-IP8989-Ag-2 Canine MTH1/NUDT1 protein Canine
GM-Tg-bovg-IP8989-Ag-1/ GM-Tg-bovg-IP8989-Ag-2 Bovine MTH1/NUDT1 protein Bovine
GM-Tg-equg-IP8989-Ag-1/ GM-Tg-equg-IP8989-Ag-2 Equine MTH1/NUDT1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8989-Ag-1/ GM-Tg-hg-IP8989-Ag-2; GM-Tg-rg-IP8989-Ag-1/ GM-Tg-rg-IP8989-Ag-2;
GM-Tg-mg-IP8989-Ag-1/ GM-Tg-mg-IP8989-Ag-2; GM-Tg-cynog-IP8989-Ag-1/ GM-Tg-cynog-IP8989-Ag-2;
GM-Tg-felg-IP8989-Ag-1/ GM-Tg-felg-IP8989-Ag-2; GM-Tg-cang-IP8989-Ag-1/ GM-Tg-cang-IP8989-Ag-2;
GM-Tg-bovg-IP8989-Ag-1/ GM-Tg-bovg-IP8989-Ag-2; GM-Tg-equg-IP8989-Ag-1/ GM-Tg-equg-IP8989-Ag-2
Products Name MTH1/NUDT1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MTH1/NUDT1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MTH1/NUDT1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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