Recombinant multi-species CIITA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CIITA protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
The Alternative Names of target: C2TA,C2ta,CIITA,CIITAIV,Ciita,EG669998,Gm9475,MHC class II transactivator,MHC2D1,MHC2TA,Mhc2ta,NLRA

Target products collectionGo to CIITA products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8835-Ag-1/ GM-Tg-hg-IP8835-Ag-2 Human CIITA protein Human
GM-Tg-rg-IP8835-Ag-1/ GM-Tg-rg-IP8835-Ag-2 Rat CIITA protein Rat
GM-Tg-mg-IP8835-Ag-1/ GM-Tg-mg-IP8835-Ag-2 Mouse CIITA protein Mouse
GM-Tg-cynog-IP8835-Ag-1/ GM-Tg-cynog-IP8835-Ag-2 Cynomolgus/Rhesus macaque CIITA protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8835-Ag-1/ GM-Tg-felg-IP8835-Ag-2 Feline CIITA protein Feline
GM-Tg-cang-IP8835-Ag-1/ GM-Tg-cang-IP8835-Ag-2 Canine CIITA protein Canine
GM-Tg-bovg-IP8835-Ag-1/ GM-Tg-bovg-IP8835-Ag-2 Bovine CIITA protein Bovine
GM-Tg-equg-IP8835-Ag-1/ GM-Tg-equg-IP8835-Ag-2 Equine CIITA protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8835-Ag-1/ GM-Tg-hg-IP8835-Ag-2; GM-Tg-rg-IP8835-Ag-1/ GM-Tg-rg-IP8835-Ag-2;
GM-Tg-mg-IP8835-Ag-1/ GM-Tg-mg-IP8835-Ag-2; GM-Tg-cynog-IP8835-Ag-1/ GM-Tg-cynog-IP8835-Ag-2;
GM-Tg-felg-IP8835-Ag-1/ GM-Tg-felg-IP8835-Ag-2; GM-Tg-cang-IP8835-Ag-1/ GM-Tg-cang-IP8835-Ag-2;
GM-Tg-bovg-IP8835-Ag-1/ GM-Tg-bovg-IP8835-Ag-2; GM-Tg-equg-IP8835-Ag-1/ GM-Tg-equg-IP8835-Ag-2
Products Name CIITA protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CIITA
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CIITA protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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