Recombinant multi-species SMAD4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD4 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasing blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, May 2022]
The Alternative Names of target: D18Wsu70e,DPC4,Deletion target in pancreatic carcinoma 4,JIP,MAD homolog 4,MADH4,MYHRS,Madh4,Mothers against DPP homolog 4,Mothers against decapentaplegic homolog 4,SMAD family member 4 (SMAD 4,SMAD4,Smad4,hSMAD4)

Target products collectionGo to SMAD4 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8776-Ag-1/ GM-Tg-hg-IP8776-Ag-2 Human SMAD4 protein Human
GM-Tg-rg-IP8776-Ag-1/ GM-Tg-rg-IP8776-Ag-2 Rat SMAD4 protein Rat
GM-Tg-mg-IP8776-Ag-1/ GM-Tg-mg-IP8776-Ag-2 Mouse SMAD4 protein Mouse
GM-Tg-cynog-IP8776-Ag-1/ GM-Tg-cynog-IP8776-Ag-2 Cynomolgus/Rhesus macaque SMAD4 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8776-Ag-1/ GM-Tg-felg-IP8776-Ag-2 Feline SMAD4 protein Feline
GM-Tg-cang-IP8776-Ag-1/ GM-Tg-cang-IP8776-Ag-2 Canine SMAD4 protein Canine
GM-Tg-bovg-IP8776-Ag-1/ GM-Tg-bovg-IP8776-Ag-2 Bovine SMAD4 protein Bovine
GM-Tg-equg-IP8776-Ag-1/ GM-Tg-equg-IP8776-Ag-2 Equine SMAD4 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8776-Ag-1/ GM-Tg-hg-IP8776-Ag-2; GM-Tg-rg-IP8776-Ag-1/ GM-Tg-rg-IP8776-Ag-2;
GM-Tg-mg-IP8776-Ag-1/ GM-Tg-mg-IP8776-Ag-2; GM-Tg-cynog-IP8776-Ag-1/ GM-Tg-cynog-IP8776-Ag-2;
GM-Tg-felg-IP8776-Ag-1/ GM-Tg-felg-IP8776-Ag-2; GM-Tg-cang-IP8776-Ag-1/ GM-Tg-cang-IP8776-Ag-2;
GM-Tg-bovg-IP8776-Ag-1/ GM-Tg-bovg-IP8776-Ag-2; GM-Tg-equg-IP8776-Ag-1/ GM-Tg-equg-IP8776-Ag-2
Products Name SMAD4 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name SMAD4
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine SMAD4 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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