Recombinant multi-species ARHGDIB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis
Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ARHGDIB protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
The Alternative Names of target: ARHGDIB,Arhgdib,D4,GDIA2,GDID4,Gdid4,LYGDI,Ly-GDI,RAP1GN1,Rho GDI 2,Rho GDP-dissociation inhibitor 2,Rho-GDI beta,RhoGDI2
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Product information
Catalog No. | Product Name | Species Reactivity |
---|---|---|
GM-Tg-hg-IP8660-Ag-1/ GM-Tg-hg-IP8660-Ag-2 | Human ARHGDIB protein | Human |
GM-Tg-rg-IP8660-Ag-1/ GM-Tg-rg-IP8660-Ag-2 | Rat ARHGDIB protein | Rat |
GM-Tg-mg-IP8660-Ag-1/ GM-Tg-mg-IP8660-Ag-2 | Mouse ARHGDIB protein | Mouse |
GM-Tg-cynog-IP8660-Ag-1/ GM-Tg-cynog-IP8660-Ag-2 | Cynomolgus/Rhesus macaque ARHGDIB protein | Cynomolgus/ Rhesus macaque |
GM-Tg-felg-IP8660-Ag-1/ GM-Tg-felg-IP8660-Ag-2 | Feline ARHGDIB protein | Feline |
GM-Tg-cang-IP8660-Ag-1/ GM-Tg-cang-IP8660-Ag-2 | Canine ARHGDIB protein | Canine |
GM-Tg-bovg-IP8660-Ag-1/ GM-Tg-bovg-IP8660-Ag-2 | Bovine ARHGDIB protein | Bovine |
GM-Tg-equg-IP8660-Ag-1/ GM-Tg-equg-IP8660-Ag-2 | Equine ARHGDIB protein | Equine |
Size: 1mg | 10mg | 100mg
Product Description
Catalog No. |
GM-Tg-hg-IP8660-Ag-1/ GM-Tg-hg-IP8660-Ag-2;
GM-Tg-rg-IP8660-Ag-1/ GM-Tg-rg-IP8660-Ag-2;
GM-Tg-mg-IP8660-Ag-1/ GM-Tg-mg-IP8660-Ag-2; GM-Tg-cynog-IP8660-Ag-1/ GM-Tg-cynog-IP8660-Ag-2; GM-Tg-felg-IP8660-Ag-1/ GM-Tg-felg-IP8660-Ag-2; GM-Tg-cang-IP8660-Ag-1/ GM-Tg-cang-IP8660-Ag-2; GM-Tg-bovg-IP8660-Ag-1/ GM-Tg-bovg-IP8660-Ag-2; GM-Tg-equg-IP8660-Ag-1/ GM-Tg-equg-IP8660-Ag-2 |
Products Name | ARHGDIB protein |
Species | Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine |
Target Name | ARHGDIB |
Protein Sub-location | Introcelluar Protein |
Isotypes | Recombinant protein |
Expression platform | Mammalian cell |
Bioactivity validation | Affintiy&bioactivity validated by ELISA, cell culture validated. |
Tag | His |
Products description | Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ARHGDIB protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic). |
Purity | Purity: ≥95% (SDS-PAGE) |
Application | In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research. |
Formulation & Reconstitution |
Lyophilized from GM's Protein Stability Buffer2
(PSB2,Confidential Ingredients) or PBS
(pH7.4); For PSB2, reconstituted with 0.9% sodium chloride; For PBS, reconstituted with ddH2O. |
Storage | Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles. |
Reference
About Gmab
GMab, developed by GeneMedi, constitutes an
advanced library of recombinant
monoclonal antibodies, each meticulously
designed to target specific molecular
entities. Leveraging the sophisticated
capabilities of GM’s Taurus™ and LIBRA™
platforms, GMab synthesizes antibodies
characterized by high binding affinity,
exceptional physicochemical stability, and
optimal developability profiles.
Through
expression in mammalian cell lines, GMab has
been established as a paradigmatic
reference antibody. It holds significance in
myriad domains of biological drug
discovery, encompassing cellular cultivation,
innovative assay methodologies,
strategic animal model systematization, in-depth
pharmacokinetic & pharmacodynamic
(PK/PD) modeling, and intricate mechanism of
action (MOA) investigations.