Recombinant multi-species INCENP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine INCENP protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM, Mar 2008]
The Alternative Names of target: 2700067E22Rik,C130081E20,INCENP,Incenp,Inner centromere protein

Target products collectionGo to INCENP products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP8305-Ag-1/ GM-Tg-hg-IP8305-Ag-2 Human INCENP protein Human
GM-Tg-rg-IP8305-Ag-1/ GM-Tg-rg-IP8305-Ag-2 Rat INCENP protein Rat
GM-Tg-mg-IP8305-Ag-1/ GM-Tg-mg-IP8305-Ag-2 Mouse INCENP protein Mouse
GM-Tg-cynog-IP8305-Ag-1/ GM-Tg-cynog-IP8305-Ag-2 Cynomolgus/Rhesus macaque INCENP protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP8305-Ag-1/ GM-Tg-felg-IP8305-Ag-2 Feline INCENP protein Feline
GM-Tg-cang-IP8305-Ag-1/ GM-Tg-cang-IP8305-Ag-2 Canine INCENP protein Canine
GM-Tg-bovg-IP8305-Ag-1/ GM-Tg-bovg-IP8305-Ag-2 Bovine INCENP protein Bovine
GM-Tg-equg-IP8305-Ag-1/ GM-Tg-equg-IP8305-Ag-2 Equine INCENP protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP8305-Ag-1/ GM-Tg-hg-IP8305-Ag-2; GM-Tg-rg-IP8305-Ag-1/ GM-Tg-rg-IP8305-Ag-2;
GM-Tg-mg-IP8305-Ag-1/ GM-Tg-mg-IP8305-Ag-2; GM-Tg-cynog-IP8305-Ag-1/ GM-Tg-cynog-IP8305-Ag-2;
GM-Tg-felg-IP8305-Ag-1/ GM-Tg-felg-IP8305-Ag-2; GM-Tg-cang-IP8305-Ag-1/ GM-Tg-cang-IP8305-Ag-2;
GM-Tg-bovg-IP8305-Ag-1/ GM-Tg-bovg-IP8305-Ag-2; GM-Tg-equg-IP8305-Ag-1/ GM-Tg-equg-IP8305-Ag-2
Products Name INCENP protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name INCENP
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine INCENP protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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