Recombinant multi-species CIC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CIC protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015]
The Alternative Names of target: 1200010B10Rik,CIC,Cic,MRD45,Protein capicua homolog,mKIAA0306

Target products collectionGo to CIC products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6748-Ag-1/ GM-Tg-hg-IP6748-Ag-2 Human CIC protein Human
GM-Tg-rg-IP6748-Ag-1/ GM-Tg-rg-IP6748-Ag-2 Rat CIC protein Rat
GM-Tg-mg-IP6748-Ag-1/ GM-Tg-mg-IP6748-Ag-2 Mouse CIC protein Mouse
GM-Tg-cynog-IP6748-Ag-1/ GM-Tg-cynog-IP6748-Ag-2 Cynomolgus/Rhesus macaque CIC protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6748-Ag-1/ GM-Tg-felg-IP6748-Ag-2 Feline CIC protein Feline
GM-Tg-cang-IP6748-Ag-1/ GM-Tg-cang-IP6748-Ag-2 Canine CIC protein Canine
GM-Tg-bovg-IP6748-Ag-1/ GM-Tg-bovg-IP6748-Ag-2 Bovine CIC protein Bovine
GM-Tg-equg-IP6748-Ag-1/ GM-Tg-equg-IP6748-Ag-2 Equine CIC protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6748-Ag-1/ GM-Tg-hg-IP6748-Ag-2; GM-Tg-rg-IP6748-Ag-1/ GM-Tg-rg-IP6748-Ag-2;
GM-Tg-mg-IP6748-Ag-1/ GM-Tg-mg-IP6748-Ag-2; GM-Tg-cynog-IP6748-Ag-1/ GM-Tg-cynog-IP6748-Ag-2;
GM-Tg-felg-IP6748-Ag-1/ GM-Tg-felg-IP6748-Ag-2; GM-Tg-cang-IP6748-Ag-1/ GM-Tg-cang-IP6748-Ag-2;
GM-Tg-bovg-IP6748-Ag-1/ GM-Tg-bovg-IP6748-Ag-2; GM-Tg-equg-IP6748-Ag-1/ GM-Tg-equg-IP6748-Ag-2
Products Name CIC protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name CIC
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine CIC protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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