Recombinant multi-species FEN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FEN1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
The Alternative Names of target: DNase IV,FEN-1,FEN1,Fen1,Flap endonuclease 1,Flap structure-specific endonuclease 1,MF1,Maturation factor 1 (MF1,RAD2,hFEN-1)

Target products collectionGo to FEN1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6562-Ag-1/ GM-Tg-hg-IP6562-Ag-2 Human FEN1 protein Human
GM-Tg-rg-IP6562-Ag-1/ GM-Tg-rg-IP6562-Ag-2 Rat FEN1 protein Rat
GM-Tg-mg-IP6562-Ag-1/ GM-Tg-mg-IP6562-Ag-2 Mouse FEN1 protein Mouse
GM-Tg-cynog-IP6562-Ag-1/ GM-Tg-cynog-IP6562-Ag-2 Cynomolgus/Rhesus macaque FEN1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6562-Ag-1/ GM-Tg-felg-IP6562-Ag-2 Feline FEN1 protein Feline
GM-Tg-cang-IP6562-Ag-1/ GM-Tg-cang-IP6562-Ag-2 Canine FEN1 protein Canine
GM-Tg-bovg-IP6562-Ag-1/ GM-Tg-bovg-IP6562-Ag-2 Bovine FEN1 protein Bovine
GM-Tg-equg-IP6562-Ag-1/ GM-Tg-equg-IP6562-Ag-2 Equine FEN1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6562-Ag-1/ GM-Tg-hg-IP6562-Ag-2; GM-Tg-rg-IP6562-Ag-1/ GM-Tg-rg-IP6562-Ag-2;
GM-Tg-mg-IP6562-Ag-1/ GM-Tg-mg-IP6562-Ag-2; GM-Tg-cynog-IP6562-Ag-1/ GM-Tg-cynog-IP6562-Ag-2;
GM-Tg-felg-IP6562-Ag-1/ GM-Tg-felg-IP6562-Ag-2; GM-Tg-cang-IP6562-Ag-1/ GM-Tg-cang-IP6562-Ag-2;
GM-Tg-bovg-IP6562-Ag-1/ GM-Tg-bovg-IP6562-Ag-2; GM-Tg-equg-IP6562-Ag-1/ GM-Tg-equg-IP6562-Ag-2
Products Name FEN1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name FEN1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine FEN1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
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