Recombinant multi-species EWS/EWSR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EWS/EWSR1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]
The Alternative Names of target: EWS,EWS oncogene,EWS-FLI1,EWSR1,Ewing sarcoma breakpoint region 1 protein,Ews,Ewsh,Ewsr1,RNA-binding protein EWS,bK984G1.4

Target products collectionGo to EWS/EWSR1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6449-Ag-1/ GM-Tg-hg-IP6449-Ag-2 Human EWS/EWSR1 protein Human
GM-Tg-rg-IP6449-Ag-1/ GM-Tg-rg-IP6449-Ag-2 Rat EWS/EWSR1 protein Rat
GM-Tg-mg-IP6449-Ag-1/ GM-Tg-mg-IP6449-Ag-2 Mouse EWS/EWSR1 protein Mouse
GM-Tg-cynog-IP6449-Ag-1/ GM-Tg-cynog-IP6449-Ag-2 Cynomolgus/Rhesus macaque EWS/EWSR1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6449-Ag-1/ GM-Tg-felg-IP6449-Ag-2 Feline EWS/EWSR1 protein Feline
GM-Tg-cang-IP6449-Ag-1/ GM-Tg-cang-IP6449-Ag-2 Canine EWS/EWSR1 protein Canine
GM-Tg-bovg-IP6449-Ag-1/ GM-Tg-bovg-IP6449-Ag-2 Bovine EWS/EWSR1 protein Bovine
GM-Tg-equg-IP6449-Ag-1/ GM-Tg-equg-IP6449-Ag-2 Equine EWS/EWSR1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6449-Ag-1/ GM-Tg-hg-IP6449-Ag-2; GM-Tg-rg-IP6449-Ag-1/ GM-Tg-rg-IP6449-Ag-2;
GM-Tg-mg-IP6449-Ag-1/ GM-Tg-mg-IP6449-Ag-2; GM-Tg-cynog-IP6449-Ag-1/ GM-Tg-cynog-IP6449-Ag-2;
GM-Tg-felg-IP6449-Ag-1/ GM-Tg-felg-IP6449-Ag-2; GM-Tg-cang-IP6449-Ag-1/ GM-Tg-cang-IP6449-Ag-2;
GM-Tg-bovg-IP6449-Ag-1/ GM-Tg-bovg-IP6449-Ag-2; GM-Tg-equg-IP6449-Ag-1/ GM-Tg-equg-IP6449-Ag-2
Products Name EWS/EWSR1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name EWS/EWSR1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine EWS/EWSR1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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