Recombinant multi-species MLKL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MLKL protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
The Alternative Names of target: 9130019I15Rik,MLKL,Mixed lineage kinase domain-like protein,Mlkl,hMLKL

Target products collectionGo to MLKL products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6305-Ag-1/ GM-Tg-hg-IP6305-Ag-2 Human MLKL protein Human
GM-Tg-rg-IP6305-Ag-1/ GM-Tg-rg-IP6305-Ag-2 Rat MLKL protein Rat
GM-Tg-mg-IP6305-Ag-1/ GM-Tg-mg-IP6305-Ag-2 Mouse MLKL protein Mouse
GM-Tg-cynog-IP6305-Ag-1/ GM-Tg-cynog-IP6305-Ag-2 Cynomolgus/Rhesus macaque MLKL protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6305-Ag-1/ GM-Tg-felg-IP6305-Ag-2 Feline MLKL protein Feline
GM-Tg-cang-IP6305-Ag-1/ GM-Tg-cang-IP6305-Ag-2 Canine MLKL protein Canine
GM-Tg-bovg-IP6305-Ag-1/ GM-Tg-bovg-IP6305-Ag-2 Bovine MLKL protein Bovine
GM-Tg-equg-IP6305-Ag-1/ GM-Tg-equg-IP6305-Ag-2 Equine MLKL protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6305-Ag-1/ GM-Tg-hg-IP6305-Ag-2; GM-Tg-rg-IP6305-Ag-1/ GM-Tg-rg-IP6305-Ag-2;
GM-Tg-mg-IP6305-Ag-1/ GM-Tg-mg-IP6305-Ag-2; GM-Tg-cynog-IP6305-Ag-1/ GM-Tg-cynog-IP6305-Ag-2;
GM-Tg-felg-IP6305-Ag-1/ GM-Tg-felg-IP6305-Ag-2; GM-Tg-cang-IP6305-Ag-1/ GM-Tg-cang-IP6305-Ag-2;
GM-Tg-bovg-IP6305-Ag-1/ GM-Tg-bovg-IP6305-Ag-2; GM-Tg-equg-IP6305-Ag-1/ GM-Tg-equg-IP6305-Ag-2
Products Name MLKL protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name MLKL
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine MLKL protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.