Recombinant multi-species DUSP6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DUSP6 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
The Alternative Names of target: 1300019I03Rik,DUSP6,Dual specificity protein phosphatase 6,Dual specificity protein phosphatase PYST1,Dusp6,HH19,MKP-3,MKP-3),MKP3,Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3,Mkp3,PYST1

Target products collectionGo to DUSP6 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6253-Ag-1/ GM-Tg-hg-IP6253-Ag-2 Human DUSP6 protein Human
GM-Tg-rg-IP6253-Ag-1/ GM-Tg-rg-IP6253-Ag-2 Rat DUSP6 protein Rat
GM-Tg-mg-IP6253-Ag-1/ GM-Tg-mg-IP6253-Ag-2 Mouse DUSP6 protein Mouse
GM-Tg-cynog-IP6253-Ag-1/ GM-Tg-cynog-IP6253-Ag-2 Cynomolgus/Rhesus macaque DUSP6 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6253-Ag-1/ GM-Tg-felg-IP6253-Ag-2 Feline DUSP6 protein Feline
GM-Tg-cang-IP6253-Ag-1/ GM-Tg-cang-IP6253-Ag-2 Canine DUSP6 protein Canine
GM-Tg-bovg-IP6253-Ag-1/ GM-Tg-bovg-IP6253-Ag-2 Bovine DUSP6 protein Bovine
GM-Tg-equg-IP6253-Ag-1/ GM-Tg-equg-IP6253-Ag-2 Equine DUSP6 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6253-Ag-1/ GM-Tg-hg-IP6253-Ag-2; GM-Tg-rg-IP6253-Ag-1/ GM-Tg-rg-IP6253-Ag-2;
GM-Tg-mg-IP6253-Ag-1/ GM-Tg-mg-IP6253-Ag-2; GM-Tg-cynog-IP6253-Ag-1/ GM-Tg-cynog-IP6253-Ag-2;
GM-Tg-felg-IP6253-Ag-1/ GM-Tg-felg-IP6253-Ag-2; GM-Tg-cang-IP6253-Ag-1/ GM-Tg-cang-IP6253-Ag-2;
GM-Tg-bovg-IP6253-Ag-1/ GM-Tg-bovg-IP6253-Ag-2; GM-Tg-equg-IP6253-Ag-1/ GM-Tg-equg-IP6253-Ag-2
Products Name DUSP6 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DUSP6
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DUSP6 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.