Recombinant multi-species ASXL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ASXL1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
The Alternative Names of target: ASXL1,Additional sex combs-like protein 1,Asxl1,BOPS,MDS,Polycomb group protein ASXL1,RGD1561878

Target products collectionGo to ASXL1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6195-Ag-1/ GM-Tg-hg-IP6195-Ag-2 Human ASXL1 protein Human
GM-Tg-rg-IP6195-Ag-1/ GM-Tg-rg-IP6195-Ag-2 Rat ASXL1 protein Rat
GM-Tg-mg-IP6195-Ag-1/ GM-Tg-mg-IP6195-Ag-2 Mouse ASXL1 protein Mouse
GM-Tg-cynog-IP6195-Ag-1/ GM-Tg-cynog-IP6195-Ag-2 Cynomolgus/Rhesus macaque ASXL1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6195-Ag-1/ GM-Tg-felg-IP6195-Ag-2 Feline ASXL1 protein Feline
GM-Tg-cang-IP6195-Ag-1/ GM-Tg-cang-IP6195-Ag-2 Canine ASXL1 protein Canine
GM-Tg-bovg-IP6195-Ag-1/ GM-Tg-bovg-IP6195-Ag-2 Bovine ASXL1 protein Bovine
GM-Tg-equg-IP6195-Ag-1/ GM-Tg-equg-IP6195-Ag-2 Equine ASXL1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6195-Ag-1/ GM-Tg-hg-IP6195-Ag-2; GM-Tg-rg-IP6195-Ag-1/ GM-Tg-rg-IP6195-Ag-2;
GM-Tg-mg-IP6195-Ag-1/ GM-Tg-mg-IP6195-Ag-2; GM-Tg-cynog-IP6195-Ag-1/ GM-Tg-cynog-IP6195-Ag-2;
GM-Tg-felg-IP6195-Ag-1/ GM-Tg-felg-IP6195-Ag-2; GM-Tg-cang-IP6195-Ag-1/ GM-Tg-cang-IP6195-Ag-2;
GM-Tg-bovg-IP6195-Ag-1/ GM-Tg-bovg-IP6195-Ag-2; GM-Tg-equg-IP6195-Ag-1/ GM-Tg-equg-IP6195-Ag-2
Products Name ASXL1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name ASXL1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine ASXL1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.