Recombinant multi-species DDX3/DDX3X protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DDX3/DDX3X protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is a member of the large DEAD-box protein family, that is defined by the presence of the conserved Asp-Glu-Ala-Asp (DEAD) motif, and has ATP-dependent RNA helicase activity. This protein has been reported to display a high level of RNA-independent ATPase activity, and unlike most DEAD-box helicases, the ATPase activity is thought to be stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. This gene has a paralog located in the nonrecombining region of the Y chromosome. Pseudogenes sharing similarity to both this gene and the DDX3Y paralog are found on chromosome 4 and the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
The Alternative Names of target: ATP-dependent RNA helicase DDX3X,CAP-Rf,D1Pas1-rs2,DBX,DDX14,DDX3,DDX3X,DDX3Y,DEAD box,DEAD box protein 3,Ddx3,Ddx3x,Fin14,HLP2,Helicase-like protein 2 (HLP2),MRX102,MRXSSB,X isoform (DBX),X-chromosomal

Target products collectionGo to DDX3/DDX3X products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

pdfMSDSpdfCOApdfDatasheet

Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6119-Ag-1/ GM-Tg-hg-IP6119-Ag-2 Human DDX3/DDX3X protein Human
GM-Tg-rg-IP6119-Ag-1/ GM-Tg-rg-IP6119-Ag-2 Rat DDX3/DDX3X protein Rat
GM-Tg-mg-IP6119-Ag-1/ GM-Tg-mg-IP6119-Ag-2 Mouse DDX3/DDX3X protein Mouse
GM-Tg-cynog-IP6119-Ag-1/ GM-Tg-cynog-IP6119-Ag-2 Cynomolgus/Rhesus macaque DDX3/DDX3X protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6119-Ag-1/ GM-Tg-felg-IP6119-Ag-2 Feline DDX3/DDX3X protein Feline
GM-Tg-cang-IP6119-Ag-1/ GM-Tg-cang-IP6119-Ag-2 Canine DDX3/DDX3X protein Canine
GM-Tg-bovg-IP6119-Ag-1/ GM-Tg-bovg-IP6119-Ag-2 Bovine DDX3/DDX3X protein Bovine
GM-Tg-equg-IP6119-Ag-1/ GM-Tg-equg-IP6119-Ag-2 Equine DDX3/DDX3X protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6119-Ag-1/ GM-Tg-hg-IP6119-Ag-2; GM-Tg-rg-IP6119-Ag-1/ GM-Tg-rg-IP6119-Ag-2;
GM-Tg-mg-IP6119-Ag-1/ GM-Tg-mg-IP6119-Ag-2; GM-Tg-cynog-IP6119-Ag-1/ GM-Tg-cynog-IP6119-Ag-2;
GM-Tg-felg-IP6119-Ag-1/ GM-Tg-felg-IP6119-Ag-2; GM-Tg-cang-IP6119-Ag-1/ GM-Tg-cang-IP6119-Ag-2;
GM-Tg-bovg-IP6119-Ag-1/ GM-Tg-bovg-IP6119-Ag-2; GM-Tg-equg-IP6119-Ag-1/ GM-Tg-equg-IP6119-Ag-2
Products Name DDX3/DDX3X protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DDX3/DDX3X
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DDX3/DDX3X protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






    About Gmab

    GDU
    GDU

    GMab, developed by GeneMedi, constitutes an advanced library of recombinant monoclonal antibodies, each meticulously designed to target specific molecular entities. Leveraging the sophisticated capabilities of GM’s Taurus™ and LIBRA™ platforms, GMab synthesizes antibodies characterized by high binding affinity, exceptional physicochemical stability, and optimal developability profiles.
    Through expression in mammalian cell lines, GMab has been established as a paradigmatic reference antibody. It holds significance in myriad domains of biological drug discovery, encompassing cellular cultivation, innovative assay methodologies, strategic animal model systematization, in-depth pharmacokinetic & pharmacodynamic (PK/PD) modeling, and intricate mechanism of action (MOA) investigations.