Recombinant multi-species DDB1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis

Genemedi produces recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DDB1 protein for cell curture, in vitro study, in vivo study, benchmark, drug discovery & MOA research and positive control for the diagnosis.
The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins. [provided by RefSeq, May 2012]
The Alternative Names of target: 127kDa,DDB p127 subunit,DDB1,DDBA,DNA damage-binding protein 1,DNA damage-binding protein a (DDBa),Damage-specific DNA-binding protein 1,Ddb1,HBV X-associated protein 1 (XAP-1),UV-DDB1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1 (UV-DDB 1),WHIKERS,XAP1,XPCE,XPE,XPE-BF,XPE-binding factor (XPE-BF),Xeroderma pigmentosum group E-complementing protein (XPCe),p127-Ddb1

Target products collectionGo to DDB1 products collection >>
(antibodies, antigen, VLP, mRNA, ORF viral vector, etc)

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Product information

Catalog No. Product Name Species Reactivity
GM-Tg-hg-IP6103-Ag-1/ GM-Tg-hg-IP6103-Ag-2 Human DDB1 protein Human
GM-Tg-rg-IP6103-Ag-1/ GM-Tg-rg-IP6103-Ag-2 Rat DDB1 protein Rat
GM-Tg-mg-IP6103-Ag-1/ GM-Tg-mg-IP6103-Ag-2 Mouse DDB1 protein Mouse
GM-Tg-cynog-IP6103-Ag-1/ GM-Tg-cynog-IP6103-Ag-2 Cynomolgus/Rhesus macaque DDB1 protein Cynomolgus/ Rhesus macaque
GM-Tg-felg-IP6103-Ag-1/ GM-Tg-felg-IP6103-Ag-2 Feline DDB1 protein Feline
GM-Tg-cang-IP6103-Ag-1/ GM-Tg-cang-IP6103-Ag-2 Canine DDB1 protein Canine
GM-Tg-bovg-IP6103-Ag-1/ GM-Tg-bovg-IP6103-Ag-2 Bovine DDB1 protein Bovine
GM-Tg-equg-IP6103-Ag-1/ GM-Tg-equg-IP6103-Ag-2 Equine DDB1 protein Equine

Size： 1mg | 10mg | 100mg



Product Description

Catalog No. GM-Tg-hg-IP6103-Ag-1/ GM-Tg-hg-IP6103-Ag-2; GM-Tg-rg-IP6103-Ag-1/ GM-Tg-rg-IP6103-Ag-2;
GM-Tg-mg-IP6103-Ag-1/ GM-Tg-mg-IP6103-Ag-2; GM-Tg-cynog-IP6103-Ag-1/ GM-Tg-cynog-IP6103-Ag-2;
GM-Tg-felg-IP6103-Ag-1/ GM-Tg-felg-IP6103-Ag-2; GM-Tg-cang-IP6103-Ag-1/ GM-Tg-cang-IP6103-Ag-2;
GM-Tg-bovg-IP6103-Ag-1/ GM-Tg-bovg-IP6103-Ag-2; GM-Tg-equg-IP6103-Ag-1/ GM-Tg-equg-IP6103-Ag-2
Products Name DDB1 protein
Species Human, Cynomolgus/ Rhesus macaque, rat, mouse, Feline, Canine, Bovine, Equine
Target Name DDB1
Protein Sub-location Introcelluar Protein
Isotypes Recombinant protein
Expression platform Mammalian cell
Bioactivity validation Affintiy&bioactivity validated by ELISA, cell culture validated.
Tag His
Products description Recombinant Human, Cynomolgus/ Rhesus macaque, Rat, Mouse, Feline, Canine, Bovine, Equine DDB1 protein was expressed in mammalian cell expression system and is expressed with 6 HIS tag at the C-terminus for cell culture, ELISA or other affinity binding assay or functional assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic).
Purity Purity: ≥95% (SDS-PAGE)
Application In vitro study, in vivo study, benchmark, positive control for the diagnosis. Biological drug disovery including cell culture, assay development, animal model development, PK/PD model development (Pharmacokinetics & Pharmacodynamic) and mechanism of action (MOA) research.
Formulation & Reconstitution Lyophilized from GM's Protein Stability Buffer2 (PSB2,Confidential Ingredients) or PBS (pH7.4);
For PSB2, reconstituted with 0.9% sodium chloride;
For PBS, reconstituted with ddH2O.
Storage Store at -20℃ to -80℃ under sterile conditions. Avoid repeated freeze-thaw cycles.

Reference






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